Effect of nutrition on neurodegenerative diseases. A systematic review.

Effect of nutrition on neurodegenerative diseases. A systematic review.

Publication date: Nov 04, 2019

Neurodegenerative diseases are characterized by the progressive functional loss of neurons in the brain, causing cognitive impairment and motoneuron disability. Although multifactorial interactions are evident, nutrition plays an essential role in the pathogenesis and evolution of these diseases. A systematic literature search was performed, and the prevalence of studies evaluated the effect of the Mediterranean diet (MeDiet), nutritional support, EPA and DHA, and vitamins on memory and cognition impairment. The data showed that malnutrition and low body mass index (BMI) is correlated with the higher development of dementia and mortality. MeDiet, nutritional support, and calorie-controlled diets play a protective effect against cognitive decline, Alzheimer’s disease (AD), Parkinson disease (PD) while malnutrition and insulin resistance represent significant risk factors. Malnutrition activates also the gut-microbiota-brain axis dysfunction that exacerbate neurogenerative process. Omega-3 and -6, and the vitamins supplementation seem to be less effective in protecting neuron degeneration. Insulin activity is a prevalent factor contributing to brain health while malnutrition correlated with the higher development of dementia and mortality.

Bianchi, V.E., Herrera, P.F., and Laura, R. Effect of nutrition on neurodegenerative diseases. A systematic review. 19447. 2019 Nutr Neurosci.

Concepts Keywords
Alzheimer Brain malnutrition
BMI Higher dementia
Body Mass Cognitive impairment
Brain Pathogenesis evolution diseases
Calorie Amyotrophic lateral sclerosis
Cognition Mediterranean diet
Cognitive Nutritional support
Cognitive Impairment Articles
Dementia RTT
DHA Health
Disability Cognitive disorders
EPA Psychiatric diagnosis
Evolution Psychiatry
Gut Microbiota Learning disabilities
Insulin Malnutrition
Insulin Resistance Dementia
Malnutrition Alzheimer’s disease
Mediterranean Diet Mediterranean diet
Memory
Mortality
Motoneuron
Neurodegenerative Diseases
Neuron
Neurons
Nutrition
Omega 3
Parkinson
Pathogenesis
Progressive
Systematic Review

Semantics

Type Source Name
disease MESH neurodegenerative diseases
pathway BSID Neurodegenerative Diseases
disease MESH cognitive impairment
drug DRUGBANK Icosapent
gene UNIPROT TIMP1
drug DRUGBANK Doconexent
pathway BSID Vitamins
disease MESH malnutrition
disease MESH development
disease MESH dementia
disease DOID dementia
disease MESH Parkinson disease
disease DOID Parkinson disease
disease MESH insulin resistance
pathway BSID Insulin resistance
disease MESH risk factors
drug DRUGBANK Omega-3 fatty acids
disease MESH neuron degeneration
gene UNIPROT INS
disease MESH amyotrophic lateral sclerosis
disease DOID amyotrophic lateral sclerosis
disease MESH Huntington disease
disease DOID Huntington disease
disease MESH multiple sclerosis
disease DOID multiple sclerosis

Original Article

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