Inhibitory effects of Euphorbia tirucalli latex on murine B16/F10 melanoma cells and lung metastasis.

Inhibitory effects of Euphorbia tirucalli latex on murine B16/F10 melanoma cells and lung metastasis.

Publication date: Nov 01, 2019

Euphorbia tirucalli (E. tirucalli) is a tropical and subtropical plant that produces a latex which is used for several purposes. The components of E. tirucalli latex include triterpenes, diterpenes and steroids. The aim of the present study was to evaluate the effects of diluted E. tirucalli latex on murine B16/F10 melanoma cells and lung metastasis. For this purpose, an in vitro study was first performed, in which B16/F10 cells were treated with diluted (1/2 to 1/11,192) E. tirucalli latex. In a second study, B16/F10 melanoma cells were inoculated into the tail vein of mice to generate lung metastases; the mice then received 0.467 ug of latex diluted in 200 ml saline by gavage for 14 days. A significant decrease in B16/F10 cell viability was observed using the MTT assay at 24 and 48 h after treatment with E. tirucalli latex. In addition, a significant decrease in the volume fraction occupied by B16/F10 metastatic colonies in the lungs was observed in mice treated with E. tirucalli latex. These results confirm the antineoplastic effects of diluted E. tirucalli latex.

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Brunetti, R.L., Da Paz, D.P.A., Da Fonseca, I.I.M., Nagamine, M.K., Mori, C.M.C., Del Grande, M.P., Queiroz-Hazarbassanov, N., Salles-Gomes, C.O.M., Dagli, M.L.Z., and Hernandez-Blazquez, F.J. Inhibitory effects of Euphorbia tirucalli latex on murine B16/F10 melanoma cells and lung metastasis. 24676. 2019 Mol Clin Oncol (11):5.

Concepts Keywords
Antineoplastic
Diterpenes
Gavage
Latex
Lung
Lungs
Melanoma
Metastases
Metastasis
Metastatic
Murine
Saline
Steroids
Subtropical
Triterpenes
Volume Fraction

Semantics

Type Source Name
gene UNIPROT FAM110A
gene UNIPROT F10
disease MESH melanoma
disease DOID melanoma
pathway BSID Melanoma
disease MESH metastasis
gene UNIPROT CD69
gene UNIPROT DNMT1

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