JNK and phosphorylated Bcl-2 predict multiple sclerosis clinical activity and glatiramer acetate therapeutic response.

JNK and phosphorylated Bcl-2 predict multiple sclerosis clinical activity and glatiramer acetate therapeutic response.

Publication date: Nov 04, 2019

In this study, we investigated the role of JNK and phospho-Bcl-2 as possible biomarkers of multiple sclerosis (MS) relapse and of glatiramer acetate (GA) therapeutic response in relapsing-remitting MS patients. We enrolled a cohort of 15 GA-treated patients and measured the expression of JNK1, JNK2, phospho-JNK and phospho-Bcl-2 through Western blotting of lysates from peripheral blood mononuclear cells collected at 0, 3, 6, and 12 months after initiating GA therapy. We found significantly higher levels of JNK1 p54 and JNK2 p54 and significantly lower levels of p-Bcl-2 in relapse patients and in GA non-responders. By using receiver operating characteristic analysis, we found that the probability of accurately detecting relapse and response to GA was: 92% and 75.5%, respectively, for JNK1 p54 and 86% and 94.6%, respectively, for p-Bcl-2. Our data suggest that JNK1 and p-Bcl-2 could serve as potential biomarkers for MS relapse and the therapeutic response to GA.

Anselmo, F., Tatomir, A., Boodhoo, D., Mekala, A.P., , Nguyen, , Rus, and Rus, H. JNK and phosphorylated Bcl-2 predict multiple sclerosis clinical activity and glatiramer acetate therapeutic response. 19427. 2019 Clin Immunol.

Concepts Keywords
Biomarkers Multiple sclerosis
Blood MS
Cohort Branches of biology
Glatiramer Acetate Medicine
JNK Programmed cell death
Multiple Sclerosis Glatiramer acetate
Phosphorylated C-Jun N-terminal kinases
Probability Apoptosis
Receiver Operating Characteristic Multiple sclerosis
Relapse MAPK8
Western Blotting Bcl-2
Relapsing–remitting

Semantics

Type Source Name
disease MESH multiple sclerosis
disease DOID multiple sclerosis
drug DRUGBANK Glatiramer
drug DRUGBANK Acetate ion
disease MESH relapse
disease DOID relapsing-remitting MS
gene UNIPROT MAPK8
gene UNIPROT MAPK9
drug DRUGBANK P54
gene UNIPROT FKBP5
gene UNIPROT ETS1
gene UNIPROT SRSF11
gene UNIPROT IFIT2

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