MS risk in immigrants in the McDonald era: A population-based study in Ontario, Canada.

MS risk in immigrants in the McDonald era: A population-based study in Ontario, Canada.

Publication date: Nov 05, 2019

To determine risk factors for multiple sclerosis (MS) in immigrants and to compare MS risk in immigrants and long-term residents in Ontario, Canada.

We applied a validated algorithm to linked, population-based immigration and health claims data to identify incident cases of MS in immigrants and long-term residents between 1994 and 2016. We conducted 2 multivariable Cox proportional hazards regression analyses: 1 analysis limited to the immigrant cohort assessing potential risk factors for developing MS, and 1 analysis comparing MS risk between immigrants and matched long-term residents (1:3 match).

We identified 2,304,302 immigrants for the immigrant-only analysis, of whom 1,526 (0.066%) developed MS. Risk was greatest in those

Rotstein, D.L., Marrie, R.A., Maxwell, C., Gandhi, S., Schultz, S.E., Fung, K., and Tu, K. MS risk in immigrants in the McDonald era: A population-based study in Ontario, Canada. 19440. 2019 Neurology.

Concepts Keywords
Algorithm MS
Canada Immigration
Cohort Population
Immigration Risk
Multiple Sclerosis Articles
Neurology Academic disciplines
Ontario Humans

Semantics

Type Source Name
disease MESH risk factors
disease MESH multiple sclerosis
disease DOID multiple sclerosis
gene UNIPROT CPOX

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