Multiple sclerosis has a distinct lipid signature in plasma and cerebrospinal fluid.

Multiple sclerosis has a distinct lipid signature in plasma and cerebrospinal fluid.

Publication date: Apr 12, 2019

The diagnosis of multiple sclerosis (MS) has changed over the last decade, but remains a composite of clinical assessment and magnetic resonance imaging to prove dissemination of lesions in time and space. The intrathecal synthesis of immunoglobulin may be a nonspecific marker and there are no plasma biomarkers that are useful in the diagnosis of MS, presenting additional challenges to their early detection.

We performed a preliminary untargeted qualitative lipidomics mass spectrometry analysis, comparing cerebrospinal fluid (CSF) and plasma samples from patients with MS, other inflammatory neurological diseases and idiopathic intracranial hypertension.

Lipid identification revealed that fatty acids and sphingolipids were the most abundant classes of lipids in the CSF and that glycerolipids and fatty acids were the main class of lipids in the plasma of patients with MS. The area under the curve was 0.995 (0.912-1) and 0.78 (0.583-0.917), respectively. The permutation test indicated that this ion combination was useful for distinguishing MS from other inflammatory diseases (p

This study concluded that the CSF and plasma from patients with MS bear a unique lipid signature that can be useful as a diagnostic biomarker.

Oliveira, E.M.L., Montani, D.A., Oliveira-Silva, D., Rodrigues-Oliveira, A.F., Matas, S.L.A., Fernandes, G.B.P., Silva, I.D.C.G.D., and Lo Turco, E.G. Multiple sclerosis has a distinct lipid signature in plasma and cerebrospinal fluid. 19423. 2019 Arq Neuropsiquiatr (77):10.

Concepts Keywords
Bear Inflammatory diseases
Biomarker Multiple sclerosis
Biomarkers Medicine
Cerebrospinal Fluid Clinical medicine
Fatty Acids Branches of biology
Glycerolipids Biotechnology
Idiopathic Intracranial Hypertension Biomarkers
Immunoglobulin Neurology
Inflammatory Diseases Lipidomics
Intrathecal Lipids
Ion Cerebrospinal fluid
Lipid Multiple sclerosis
Lipids Magnetic resonance imaging
Magnetic Resonance Imaging Multiple sclerosis biomarkers
Mass Spectrometry Lipidomics
Multiple Sclerosis Magnetic resonance imaging
Permutation Test


Type Source Name
disease MESH Multiple sclerosis
disease DOID Multiple sclerosis
disease MESH diagnosis
disease MESH idiopathic intracranial hypertension
disease DOID idiopathic intracranial hypertension
pathway BSID Fatty acids


Original Article

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