Novel Targets for the Treatment of Melanoma.

Novel Targets for the Treatment of Melanoma.

Publication date: Nov 06, 2019

In this article, we will briefly review the current treatment landscape for metastatic melanoma and provide a comprehensive update on emerging novel treatment strategies.

Over the past decade, remarkable advances in immunotherapy and targeted therapy have greatly improved outcomes for patients with advanced melanoma. Although a subset of patients is able to achieve durable responses, the majority experience eventual disease progression on existing therapies. Trials evaluating novel combinatorial strategies, checkpoint inhibitors, immune agonists, T cell-based therapies, intratumoral agents, and others are ongoing. While strides have been made in the treatment of advanced melanoma, further research is needed to identify alternative immune and molecular targets in order to overcome resistance and achieve better clinical outcomes.

Ambrosi, L., Khan, S., Carvajal, R.D., and Yang, J. Novel Targets for the Treatment of Melanoma. 24711. 2019 Curr Oncol Rep (21):11.

Concepts Keywords
Combinatorial Immunotherapy
Immunotherapy MEK inhibitor
Melanoma Targeted therapy
Targeted Therapy Melanoma
Checkpoint inhibitor
Antineoplastic drugs
Immune system
Cancer treatments
Cancer
Clinical medicine
Medicine
Immunotherapy
Metastatic melanoma
Targets Treatment Melanoma

Semantics

Type Source Name
gene UNIPROT CD274
gene UNIPROT RPL17
gene UNIPROT CTLA4
gene UNIPROT BRAF
drug DRUGBANK Tropicamide
disease MESH disease progression
gene UNIPROT EHD1
pathway BSID Melanoma
disease DOID Melanoma
disease MESH Melanoma

Original Article

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