The sirtuin 6: An overture in skin cancer.

The sirtuin 6: An overture in skin cancer.

Publication date: Nov 07, 2019

In the recent past, the sirtuins have been under intense investigation for their roles in biology and disease, including cancer. The sirtuin SIRT6 is comparatively a lesser studied member of this family of seven proteins. Like certain other sirtuins, SIRT6 isemerging to have an oncogenic function as well as tumor suppressor roles in cancer. Limited studies have been conducted assessing the role and functional significance of SIRT6 in melanoma and non-melanoma skin cancers. In this review, we have attempted to critically dissect the potential role and significance of SIRT6 in skin carcinogenesis. With limited available information to date, SIRT6 appears to have a pro-proliferative function in non-melanoma skin cancers (NMSCs), including squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). In addition, SIRT6 is also emerging to have an oncogenic function in melanoma. Moreover, we have provided information regarding the available SIRT6 inhibitors. Conclusively, it appears that additional comprehensive studies are needed to establish the role of SIRT6 in skin biology and skin diseases, including cancer. Further, concerted efforts are needed to characterize the stage-specific role of SIRT6 in skin cancers.

Garcia-Peterson, L.M., Guzm’an-P’erez, G., Krier, C.R., and Ahmad, N. The sirtuin 6: An overture in skin cancer. 24684. 2019 Exp Dermatol.

Concepts Keywords
Basal Cancer
Cancer RTT
Carcinogenesis Sirtuin 6
Carcinoma Health
Melanoma Branches of biology
Oncogenic Skin cancer
Overture Medical education
Sirtuin Melanoma
Sirtuins
Skin Cancer
Squamous Carcinoma
Tumor Suppressor

Semantics

Type Source Name
disease MESH skin cancer
disease DOID skin cancer
gene UNIPROT EHD1
disease MESH cancer
disease DOID cancer
gene UNIPROT SIRT6
disease MESH melanoma
disease DOID melanoma
pathway BSID Melanoma
disease MESH carcinogenesis
disease MESH squamous cell carcinoma
disease DOID squamous cell carcinoma
disease MESH basal cell carcinoma
disease DOID basal cell carcinoma
pathway BSID Basal cell carcinoma
disease MESH skin diseases

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