Translational pathology, genomics and the development of systemic therapies for acral melanoma.

Translational pathology, genomics and the development of systemic therapies for acral melanoma.

Publication date: Nov 02, 2019

Acral melanomas arise on the non-hair bearing skin of the palms, soles and in the nail beds. These rare tumors comprise 2-3% of all melanomas, are not linked to UV-exposure, and represent the most frequent subtype of melanomas in patients of Asian, African and Hispanic origin. Although recent work has revealed candidate molecular events that underlie acral melanoma development, this knowledge is not yet been translated into efficacious local, regional, or systemic therapies. In the current review, we describe the clinical characteristics of acral melanoma and outline the genetic basis of acral melanoma development. Further discussion is given to the current status of systemic therapy for acral melanoma with a focus on ongoing developments in both immunotherapy and targeted therapy for the treatment of advanced disease.

Chen, Y.A., Teer, J.K., Eroglu, Z., Wu, J.Y., Koomen, J.M., Karreth, F.A., Messina, J.L., and Smalley, K.S.M. Translational pathology, genomics and the development of systemic therapies for acral melanoma. 24701. 2019 Semin Cancer Biol.

Concepts Keywords
Asian Melanomas
Genetic Immunotherapy
Hispanic Melanoma
Immunotherapy Medicine
Melanoma Clinical medicine
Melanomas Acral lentiginous melanoma
Nail Beds Health
Outline Immunotherapy
Pathology Targeted therapy
Systemic Therapy
Targeted Therapy
UV

Semantics

Type Source Name
disease MESH development
disease MESH melanoma
disease DOID melanoma
pathway BSID Melanoma
gene UNIPROT CD244
disease MESH tumors

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