Primary diffuse meningeal melanomatosis – a rare form of meningeal melanoma: case report.

Primary diffuse meningeal melanomatosis – a rare form of meningeal melanoma: case report.

Publication date: Nov 05, 2019

Meningeal melanomatosis is a rare type of central nervous system neoplasm (with incidence ranging between 3 and 5%) that develops in the course of malignant melanoma. In a small percentage of cases, meningeal melanomatosis may develop without a primary focus. It affects the leptomeninx. The clinical activity of the disease is uncharacteristic, with a number of neurological symptoms developing over weeks or months.

A 45-year-old male patient presented with consciousness disturbance, cognitive dysfunctions, seizures and progressive paresis. None of the examinations performed, including cerebrospinal fluid examination, neuroimaging and biopsy of the leptomeninges, permitted us to establish a diagnosis during the patient’s hospital stay. The diagnosis of meningeal melanomatosis was established after an autopsy had been carried out.

In the absence of unequivocal test results, it is also worth taking into account the primary changes in the leptomeninx, including those caused by melanoma.

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Garbacz, T., Osuchowski, M., and Bartosik-Psujek, H. Primary diffuse meningeal melanomatosis – a rare form of meningeal melanoma: case report. 24697. 2019 BMC Neurol (19):1.

Concepts Keywords
A 45 Malignant melanoma
Autopsy Medicine
Biopsy Clinical medicine
BMC Melanoma
Central Nervous System RTT
Cerebrospinal Fluid Medical specialties
Cognitive Cancer
Consciousness Meninges
Hospital Biopsy
Incidence Brain tumor
Leptomeninges Meningeal carcinomatosis
Malignant Melanoma
Melanoma
Neoplasm
Neuroimaging
Neurological
Paresis
Progressive
Seizures

Semantics

Type Source Name
disease DOID meningeal melanomatosis
disease DOID meningeal melanoma
disease MESH malignant melanoma
disease DOID malignant melanoma
disease MESH cognitive dysfunctions
disease MESH seizures
disease MESH paresis
disease MESH diagnosis
pathway BSID Melanoma
disease MESH growth
disease DOID melanomatosis
drug DRUGBANK Methyprylon
disease MESH meningitis
disease DOID meningitis
disease MESH malignancy
disease MESH spinal cord compression
gene UNIPROT MAGEE1
disease MESH typ
disease MESH viral encephalitis
disease DOID viral encephalitis
disease MESH lymphoma
disease DOID lymphoma
gene UNIPROT ERBB2
disease MESH carcinoma
disease DOID carcinoma
gene UNIPROT MEN1
disease DOID cancer
drug DRUGBANK Coenzyme M
gene UNIPROT CSF2
drug DRUGBANK Dextrose unspecified form
disease MESH pleocytosis
drug DRUGBANK Ceftazidime
disease MESH Infectious Diseases
drug DRUGBANK Ceftriaxone
drug DRUGBANK Acyclovir
drug DRUGBANK Dexamethasone
gene UNIPROT CDK9
disease DOID infectious disease
pathway BSID Infectious disease
gene UNIPROT CYREN
disease MESH hepatitis
disease DOID hepatitis
drug DRUGBANK Trestolone
gene UNIPROT MENT
drug DRUGBANK Gadolinium
disease MESH infections
disease MESH abnormalities
gene UNIPROT BPIFA4P
gene UNIPROT SPG7
gene UNIPROT NR1I3
gene UNIPROT CASR
gene UNIPROT CXADR
gene UNIPROT ARR3
disease MESH sarcoidosis
disease DOID sarcoidosis
disease MESH arrhythmia
disease MESH death
gene UNIPROT IK
drug DRUGBANK Honey
gene UNIPROT REM1
disease DOID LCA
gene UNIPROT CLTA
disease DOID neoplasm
disease MESH men
disease MESH hydrocephalus
disease DOID hydrocephalus
disease MESH ataxia
disease MESH cranial nerve palsies
disease MESH tuberculous meningitis
disease MESH tuberculosis
disease DOID tuberculosis
pathway BSID Tuberculosis
drug DRUGBANK Choline
drug DRUGBANK Acetylsalicylic acid
gene UNIPROT ARSA
drug DRUGBANK Dacarbazine
disease DOID Sch
gene UNIPROT NF2
drug DRUGBANK Iron
gene UNIPROT FER
gene UNIPROT LARGE1
drug DRUGBANK Vemurafenib
gene UNIPROT BRAF
disease MESH suffering
gene UNIPROT JUN
gene UNIPROT DESI1
gene UNIPROT SLC35G1
gene UNIPROT LRP1
gene UNIPROT ACTA1
disease MESH metastases

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