Publication date: Nov 05, 2019
Meningeal melanomatosis is a rare type of central nervous system neoplasm (with incidence ranging between 3 and 5%) that develops in the course of malignant melanoma. In a small percentage of cases, meningeal melanomatosis may develop without a primary focus. It affects the leptomeninx. The clinical activity of the disease is uncharacteristic, with a number of neurological symptoms developing over weeks or months.
A 45-year-old male patient presented with consciousness disturbance, cognitive dysfunctions, seizures and progressive paresis. None of the examinations performed, including cerebrospinal fluid examination, neuroimaging and biopsy of the leptomeninges, permitted us to establish a diagnosis during the patient’s hospital stay. The diagnosis of meningeal melanomatosis was established after an autopsy had been carried out.
In the absence of unequivocal test results, it is also worth taking into account the primary changes in the leptomeninx, including those caused by melanoma.
Open Access PDF
Garbacz, T., Osuchowski, M., and Bartosik-Psujek, H. Primary diffuse meningeal melanomatosis – a rare form of meningeal melanoma: case report. 24697. 2019 BMC Neurol (19):1.
- GNAQ expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system.
- Genomic Analysis Reveals Low Tumor Mutation Burden Which May be Associated with GNAQ/11 Alteration in a Series of Primary Leptomeningeal Melanomas.