Researchers report new insights into Parkinson’s disease-related mortality

Researchers report new insights into Parkinson’s disease-related mortality

Publication date: Nov 09, 2019

Credit: CC0 Public Domain By following a group of newly diagnosed patients with Parkinson’s disease (PD) for a decade or more, researchers have been able to identify several factors never before reported that appear to be associated with higher mortality rates in PD patients compared to the general population.

As reported in the Journal of Parkinson’s Disease, these factors are early onset of PD, early impairment of memory and thinking, and early motor symptoms requiring the start of drug therapy.

This study differed from previous studies of mortality in PD patients because of its focus on factors affecting mortality related to PD.

The investigators found that earlier onset of PD, early impairment of memory and thinking, and higher daily antiparkinson medication use (measured in levodopa equivalent dose) were all associated with PD-related mortality.

Nonetheless, individualized care starts with a better understanding of differences between patients, and our findings show that individual differences in the manifestation of PD are associated with life expectancy,” noted lead author Jeroen Hoogland, MSc, who is also affiliated with the Department of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

Concepts Keywords
Amsterdam Related neurodegenerative disorder
Antiparkinson Medication Disease
CC0 Slowly progressive disorder
Drug Therapy Drug therapy
Equivalent Dose Demography
Fair Dealing Academic disciplines
General Cognitive Ability Environmental social science
Heterogeneity Life expectancy
Levodopa
Memory
Mini
Mortality
MSc
Muscle
Netherlands
Neurodegenerative Disorder
Neurology
Parkinson
Progressive

Semantics

Type Source Name
disease MESH death
drug DRUGBANK Levodopa
gene UNIPROT PLXNA3
drug DRUGBANK Tropicamide
gene UNIPROT MSC
drug DRUGBANK Isoxaflutole
disease MESH neurodegenerative disorder

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