Publication date: Nov 09, 2019
Credit: CC0 Public Domain By following a group of newly diagnosed patients with Parkinson’s disease (PD) for a decade or more, researchers have been able to identify several factors never before reported that appear to be associated with higher mortality rates in PD patients compared to the general population.
As reported in the Journal of Parkinson’s Disease, these factors are early onset of PD, early impairment of memory and thinking, and early motor symptoms requiring the start of drug therapy.
This study differed from previous studies of mortality in PD patients because of its focus on factors affecting mortality related to PD.
The investigators found that earlier onset of PD, early impairment of memory and thinking, and higher daily antiparkinson medication use (measured in levodopa equivalent dose) were all associated with PD-related mortality.
Nonetheless, individualized care starts with a better understanding of differences between patients, and our findings show that individual differences in the manifestation of PD are associated with life expectancy,” noted lead author Jeroen Hoogland, MSc, who is also affiliated with the Department of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.