Telomere length analysis on leukocytes derived from patients with Huntington Disease.

Telomere length analysis on leukocytes derived from patients with Huntington Disease.

Publication date: Nov 21, 2019

Huntington’s disease (HD) is a neurodegenerative disorder characterized by neuropsychiatric, motor and cognitive manifestations. It is caused by expansion of the trinucleotide CAG on HTT. The molecular bases are not completely understood, DNA damage, such as double and single strand breaks and oxidative stress (OS) have been implicated. At telomeres, DNA breaks are less efficiently repaired. Double strand breaks evoke the break induced replication (BIR) mechanism. BIR, plus inefficient repair can produce telomere shortening and cellular senescence. Our aim was to investigate the correlation between leukocyte relative telomeric length (RTL) and HD.

206 samples were analyzed, 71 patients with molecular diagnosis and symptomatology (HD), 29 individuals with positive molecular test but asymptomatic (PP) and 106 healthy individuals (NP).

We found a significant difference in RTL between HD patients compared with both, PP and NP, independently of subjects’ age.

Here we present evidence supporting an association between telomere shortening and HD. Telomere shortening could be related to DNA damage caused by ROS and defective DNA repair mechanism. Both events have been probed to occur in the presence of a mutant Huntingtin. This study contributes with current evidence suggesting a potential role of telomere shortening as HD biomarker.

PerezGrovas-Saltijeral, A., Ochoa-Morales, A., Miranda-Duarte, A., Mart’inez-Ruano, L., Jara-Prado, A., Camacho-Molina, A., and Hidalgo-Bravo, A. Telomere length analysis on leukocytes derived from patients with Huntington Disease. 06793. 2019 Mech Ageing Dev.

Concepts Keywords
Asymptomatic Huntingtin
Biomarker Telomeres
Cellular Senescence Molecular biology
Cognitive Senescence
Correlation Chromosomes
Huntingtin Branches of biology
Huntington Neurodegenerative disorder
Leukocyte Neurodegeneration
Leukocytes Cellular senescence
Mutant Huntington’s disease
Neurodegenerative Disorder Shelterin
Neuropsychiatric
NP
Oxidative Stress
ROS
RTL
Telomere
Telomeres
Telomeric

Semantics

Type Source Name
disease MESH Huntington Disease
pathway KEGG Huntington disease
disease MESH neurodegenerative disorder
disease MESH DNA damage
disease MESH oxidative stress
disease MESH telomere shortening
pathway KEGG Cellular senescence
disease MESH diagnosis

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