Common Mechanisms of Blood-Brain Barrier Dysfunction to Underlie Many Forms of Damage to the Brain

Common Mechanisms of Blood-Brain Barrier Dysfunction to Underlie Many Forms of Damage to the Brain

Publication date: Nov 26, 2019

The specialized cells of the blood-brain barrier line blood vessels that pass through the central nervous system, managing the passage of molecules and cells. Whether in the wake of a stroke, seizure, massive neuroinflammation, or a blow to the head, the endothelial cells of the blood-brain barrier (BBB) respond with remarkable similarity, according to a new study. The findings suggest that common mechanisms of BBB dysfunction underlie different brain injuries and diseases. “This raises the possibility that successfully preventing (or increasing) endothelial cell gene-expression changes that occur in .. . Semin Neurol 2019; 39: 383-390 DOI: infections of the central nervous system are classically associated with immunosuppression arising from infection with human immunodeficiency virus and with various hematologic malignancies. Paralysis can be complete or incomplete at prese. .. Shanshan Zhang1, Dongli Yuan2 and Ge Tan1* 1Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 2The Institute of Medical Information, Chongqing Medical University, Chongqing, China Primary systemic vasculitis can affect every structure in both the central and peripheral nervous system, causing varied neurological manifestations of neurological dysfunction. This review highlights the clinical manifestations of primary systemic vasc. .. Effects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Expression and Properties in Neurodegeneration and Injury Conclusion and Future Aspects This review summarizes available NTF expression data, compiles existing evidence on the effects of glial NTF signaling in healthy conditions and in disease models (Figure 1), and highlights the importance of this topic for future studies. Given that HAM/TSP is characterized by activated T-cells in both the periphery and CNS, studies in HAM/TSP will be highly informative for clarifying the pathogenesis of other neuroinflammatory disorders such as multiple sclerosis. … Phagocytosis in the Brain: Homeostasis and Disease Conclusions and Perspectives In this review we have summarized the critical role phagocytosis plays in both CNS homeostasis and disease. Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP β/ζ Axis: Relevance in Therapeutic Development Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Which are the functions of MK and PTN in chronic neuroinfla. .. We have long been told to eat less salt as a high salt diet can lead to high blood pressure, which in turn is a risk factor for a host of health problems including heart disease and stroke.

Concepts Keywords
Aging Heart stroke
Autoimmune Diseases Abnormal movement
Axis Autoimmune diseases
BDNF Immunosuppression
Blood Branches of biology
Blood Brain Barrier Neurology
BP Organ systems
Brain Glial cells
Brain Inflammation Nervous system
Central Nervous System Neuroinflammation
China Blood–brain barrier
Chongqing Microglia
Chongqing University Pericyte
Clinical Trials Utilization technologies
Common Transplantation
Endothelial Gene expression
Etiologies Good evidence dysfunction
Facial Nerve Significant neurodegenerative disorders
Facial Nerve Paralysis Early neurodegenerative diseases
Facial Paralysis Immune inflammatory diseases
GDNF Diseases
Gene Pathogenesis neuroinflammatory disorders
Glia Homeostasis disease
Glial Paralysis
Heart Stroke DOI infections
Hematologic Malignancies Imaging
High Blood Pressure Utilization technologies
Homeostasis
HTLV
Immunodeficiency
Immunosuppression
Immunosuppressive
Infection
Inflammation
Inflammatory Diseases
Irritable Bowel Syndrome
Longevity
Microenvironment
Microglia
Mimicry
Morbidity
Mortality
Motor Disability
Multiple Sclerosis
Neurodegeneration
Neurodegenerative Diseases
Neurodegenerative Disorders
Neurological
Neurology
Neurotrophic Factors
Pathogenesis
Pathology
Peripheral Nervous System
Phagocytic
Phagocytosis
Physical Examination
Prognosis
Risk Factor
Salt
Science Progress
Scientific Community
Seizure
Shanshan
Sir Charles Bell
Stimulus
Stroke
Synapse
T Cells
Throughput
Vasculitis
Virus
Vivo

Semantics

Type Source Name
disease MESH heart disease
disease MESH risk factor
disease MESH high blood pressure
disease MESH Development
disease MESH multiple sclerosis
drug DRUGBANK Tropicamide
disease MESH neurological manifestations
disease MESH systemic vasculitis
disease MESH abnormal movement
disease MESH facial paralysis
disease MESH palsy
disease MESH autoimmune diseases
disease MESH hematologic malignancies
disease MESH infections
disease MESH stroke
disease MESH inflammation
pathway REACTOME Neurodegenerative Diseases
disease MESH neurodegenerative diseases
disease MESH pathology
disease MESH irritable bowel syndrome
disease MESH Aging
disease MESH frailty
disease MESH suffering
disease MESH community

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