New strategy could help cells get rid of disease-related debris

New strategy could help cells get rid of disease-related debris

Publication date: Nov 28, 2019

However, little is known about the details of autophagy, such as how the cell knows which components to tag with ubiquitin.

The researchers wondered if guanine tagging could also initiate autophagy against other cellular components.

Different AUTACs successfully targeted and tagged specific intracellular proteins for autophagy, the researchers report.

The AUTAC successfully targeted fragmented mitochondria in cells taken from someone with Down syndrome.

Concepts Keywords
Aging Mitophagy
Autophagy Mitochondrion
Bacteria Ubiquitin
Biologist Neurodegeneration
Chimera Mitochondria
Dementia Senescence
Guanine Immunology
Hearing Loss Autophagy
Heart Disease Programmed cell death
Intracellular Branches of biology
Metabolic Diseases Fragmented mitochondria syndrome
Mitochondria Cancers
Mitochondrial Membrane Neurodegenerative metabolic diseases
Molecule Chemical
Neurodegenerative
Nucleic Acid
Organelles
Streptococci
Syndrome
Tohoku
Tohoku University
Ubiquitin
Vacuoles
Warhead

Semantics

Type Source Name
disease MESH cancers
pathway KEGG Autophagy
disease MESH aging
disease MESH Down syndrome
disease MESH metabolic diseases
drug DRUGBANK Guanine
disease MESH development
disease MESH heart disease
disease MESH hearing loss
disease MESH dementia

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