Publication date: Nov 28, 2019
However, little is known about the details of autophagy, such as how the cell knows which components to tag with ubiquitin.
The researchers wondered if guanine tagging could also initiate autophagy against other cellular components.
Different AUTACs successfully targeted and tagged specific intracellular proteins for autophagy, the researchers report.
The AUTAC successfully targeted fragmented mitochondria in cells taken from someone with Down syndrome.
- Bioinformatics analysis of Ras homologue enriched in the striatum, a potential target for Huntington’s disease therapy.