Embedded 3D Printing of Novel Bespoke Soft Dosage Form Concept for Pediatrics.

Embedded 3D Printing of Novel Bespoke Soft Dosage Form Concept for Pediatrics.

Publication date: Nov 26, 2019

Embedded three-dimensional printing (e-3DP) is an emerging method for additive manufacturing where semi-solid materials are extruded within a solidifying liquid matrix. Here, we present the first example of employing e-3DP in the pharmaceutical field and demonstrate the fabrication of bespoke chewable dosage forms with dual drug loading for potential use in pediatrics. Lego-like chewable bricks made of edible soft material (gelatin-based matrix) were produced by directly extruding novel printing patterns of model drug ink (embedded phase) into a liquid gelatin-based matrix (embedding phase) at an elevated temperature (70 ^0C) to then solidify at room temperature. Dose titration of the two model drugs (paracetamol and ibuprofen) was possible by using specially designed printing patterns of the embedded phase to produce varying doses. A linearity [R = 0.9804 (paracetamol) and 0.9976 (ibuprofen)] was achieved between percentage of completion of printing patterns and achieved doses using a multi-step method. The impact of embedded phase rheological behavior, the printing speed and the needle size of the embedded phase were examined. Owning to their appearance, modular nature, ease of personalizing dose and geometry, and tailoring and potential inclusion of various materials, this new dosage form concept holds a substantial promise for novel dosage forms in pediatrics.

Rycerz, K., Stepien, K.A., Czapiewska, M., Arafat, B.T., Habashy, R., Isreb, A., Peak, M., and Alhnan, M.A. Embedded 3D Printing of Novel Bespoke Soft Dosage Form Concept for Pediatrics. 05860. 2019 Pharmaceutics (11):12.

Concepts Keywords
Additive Manufacturing Dimensional printing
Bespoke Percentage completion printing
Dosage Form Printing embedded phase
Gelatin Drugs
Geometry Pharmacology
Ibuprofen Health
Ink RTT
Lego Hepatotoxins
Matrix Analgesics
Paracetamol Dosage forms
Pediatrics Nonsteroidal anti-inflammatory drugs
Pharmaceutical Paracetamol
Pharmaceutics Tablet
Rheological Ibuprofen
Temperature 3D printing
Titration

Semantics

Type Source Name
drug DRUGBANK Gelatin
drug DRUGBANK Acetaminophen
drug DRUGBANK Ibuprofen
disease MESH multi

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