Pathophysiology and Therapeutic Perspectives of Oxidative Stress and Neurodegenerative Diseases: A Narrative Review.

Pathophysiology and Therapeutic Perspectives of Oxidative Stress and Neurodegenerative Diseases: A Narrative Review.

Publication date: Nov 28, 2019

Neurodegeneration is the term describing the death of neurons both in the central nervous system and periphery. When affecting the central nervous system, it is responsible for diseases like Alzheimer’s disease, Parkinson’s disease, Huntington’s disorders, amyotrophic lateral sclerosis, and other less frequent pathologies. There are several common pathophysiological elements that are shared in the neurodegenerative diseases. The common denominators are oxidative stress (OS) and inflammatory responses. Unluckily, these conditions are difficult to treat. Because of the burden caused by the progression of these diseases and the simultaneous lack of efficacious treatment, therapeutic approaches that could target the interception of development of the neurodegeneration are being widely investigated. This review aims to highlight the most recent proposed novelties, as most of the previous approaches have failed. Therefore, older approaches may currently be used by healthcare professionals and are not being presented.

This review was based on an electronic search of existing literature, using PubMed as primary source for important review articles, and important randomized clinical trials, published in the last 5 years. Reference lists from the most recent reviews, as well as additional sources of primary literature and references cited by relevant articles, were used.

Eighteen natural pharmaceutical substances and 24 extracted or recombinant products, and artificial agents that can be used against OS, inflammation, and neurodegeneration were identified. After presenting the most common neurodegenerative diseases and mentioning some of the basic mechanisms that lead to neuronal loss, this paper presents up to date information that could encourage the development of better therapeutic strategies.

This review shares the new potential pharmaceutical and not pharmaceutical options that have been recently introduced regarding OS and inflammatory responses in neurodegenerative diseases.

Rekatsina, M., Paladini, A., Piroli, A., Zis, P., Pergolizzi, J.V., and Varrassi, G. Pathophysiology and Therapeutic Perspectives of Oxidative Stress and Neurodegenerative Diseases: A Narrative Review. 06799. 2019 Adv Ther.

Concepts Keywords
Alzheimer Neuroprotection
Amyotrophic Lateral Sclerosis Neurology
Artificial Agents Senescence
Central Nervous System Branches of biology
Healthcare Neurodegeneration
Huntington Neuroscience
Inflammation Organ systems
Interception Amyotrophic lateral sclerosis
Neurodegeneration Disorders
Neurodegenerative Diseases Common neurodegenerative diseases
Neurons Neurodegenerative diseases
Oxidative Stress Inflammatory Neurodegenerative diseases
Parkinson Healthcare professionals
Pathologies Progression diseases
Pathophysiological Natural pharmaceutical substances
Pharmaceutical Recombinant products
PubMed Electronic search
Randomized Clinical Trials


Type Source Name
disease MESH Cognitive decline
drug DRUGBANK Tropicamide
disease MESH inflammation
disease MESH development
disease MESH amyotrophic lateral sclerosis
disease MESH death
pathway REACTOME Neurodegenerative Diseases
disease MESH Neurodegenerative Diseases
disease MESH Oxidative Stress


Original Article

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