Using rTMS to Explore Neural Mechanisms of Stress-Induced Opioid Use

Using rTMS to Explore Neural Mechanisms of Stress-Induced Opioid Use

Publication date: Nov 28, 2019

This study will use a stress (vs. placebo) exposure model, paired with single-session sham vs. active rTMS at two distinct cortical locations (dlPFC vs. mPFC in parallel groups) to assess whether rTMS neuromodulation at these alternative loci differentially influence stress-reactivity and opioid reinforcement in non-treatment seeking participants with OUD. Stress-reactivity will be measured using cognitive, affective, behavioral and biological phenotypes.

Concepts Keywords
Addiction Neuroscience
Alcohol Branches of biology
Bpm Nervous system
Cardiovascular Neuropsychology
Cognitive Neurotechnology
Cortical Cerebral cortex
Diastolic Neurophysiology
Dorsolateral Prefrontal Cortex Mood disorders
DSM Dorsolateral prefrontal cortex
Endogenous Transcranial magnetic stimulation
Hydrocortisone Reward system
Lactating Neuromodulation
Limbic
Loci
Marijuana
Medial Prefrontal Cortex
MmHg
Neuromodulation
Opioid
Pharmacological
Phenotypes
Placebo
Reward Circuitry
RTMS
Shipley
Stress
Stressor
Systolic
Yohimbine

Semantics

Type Source Name
drug DRUGBANK Ethanol
drug DRUGBANK Medical Cannabis

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