A comparative study of bilateral subthalamic nucleus DBS in Parkinson’s disease in young versus old: A single institutional study.

A comparative study of bilateral subthalamic nucleus DBS in Parkinson’s disease in young versus old: A single institutional study.

Publication date: Dec 01, 2019

To compare outcome between young [65?yrs] patients of Parkinson’s disease who underwent bilateral STN DBS a non-randomized retrospective study was done. 20 young (Young group) and 20 elderly (Old group) patients with matched baseline UPDRS were selected and followed up for 2?years after deep brain stimulation (DBS) surgery. The total and motor UPDRS, before, one year and two years after surgery was compared. PDQ39 a quality of life questionnaire and MMSE were also recorded. Zarit care burden interview (ZCBI) was used to analyse caregiver burden. Analysis of data was done using Mann-Whitney Test as the data was ordinal. The difference was not statistically significant at 1st and 2nd year of follow up in total and motor UPDRS. A significant reduction in Levodopa equivalent daily dose was seen in young and old group from preoperative period to 1st & then 2nd year of follow up. The difference was not statistically significant (P?=?0.946) at 1st (P?=?0.946) and at 2nd year (P?=?0.989). Both the groups showed improvement in their PDQ39. The difference was not statistically significant at 1st (P?=?0.636) and at 2nd year of follow up (P?=?0.417). Caregiver burden (ZCBI) improved in both the groups and the difference was not statistically significant at 1st (P?=?0.105) and at 2nd year of follow up (P?=?0.078).In this study STN DBS didn’t lead to any cognitive decline (MMSE) whatever is the age of patient during follow up. Bilateral STN DBS for Parkinson’s disease is equally effective in young and elderly patients.

Vats, A., Amit, A., and Doshi, P. A comparative study of bilateral subthalamic nucleus DBS in Parkinson’s disease in young versus old: A single institutional study. 23131. 2019 J Clin Neurosci (70):

Concepts Keywords
Caregiver Deep brain stimulation
Cognitive Surgery
DBS Medicine
Deep Brain Stimulation Clinical medicine
Levodopa Medical specialties
Parkinson Aging-associated diseases
Questionnaire Psychiatric diagnosis
Subthalamic Nucleus RTT
Test Neurosurgical procedures
Parkinson’s disease
Deep brain stimulation
Subthalamic nucleus
STN

Semantics

Type Source Name
drug DRUGBANK Levodopa
disease MESH cognitive decline

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