Publication date: Dec 01, 2019
Two new series of heterocyclic derivatives with potential anticancer activity, in which a pyrrolo[1,2-b]pyridazine or a pyrrolo[2,1-a]phthalazine moiety was introduced in place of the 3′-hydroxy-4′-methoxyphenyl ring of phenstatin have been synthesised and their structure-activity relationship (SAR) was studied. Fourteen of the new compounds were evaluated for their in vitro cytotoxic activity by National Cancer Institute (NCI) against 60 human tumour cell lines panel. The best five compounds in terms of in vitro growth inhibition were screened in the second stage five dose-response studies, three of them showing a very good antiproliferative activity with GI
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Popovici, L., Amarandi, R.M., , Mangalagiu, , Mangalagiu, and Danac, R. Synthesis, molecular modelling and anticancer evaluation of new pyrrolopyridazine and pyrrolophthalazine derivatives. 24981. 2019 J Enzyme Inhib Med Chem (34):1.
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