Oncologic outcomes, prognostic factor analysis and therapeutic algorithm evaluation of head and neck mucosal melanomas in France.

Oncologic outcomes, prognostic factor analysis and therapeutic algorithm evaluation of head and neck mucosal melanomas in France.

Publication date: Dec 01, 2019

Head and neck mucosal melanoma (HNMM) is aggressive and rare, with a poor prognosis because of its high metastatic potential. The two main subtypes are sinonasal (sinonasal mucosal melanoma [SNMM]) and oral cavity (oral cavity mucosal melanoma [OCMM]). Consensual therapeutic guidelines considering the primary tumour site and tumour-node-metastasis (TNM) stage are not well established.

Patients with HNMM from the prospective national French Rare Head and Neck Cancer Expert Network database between 2000 and 2017 were included. Clinical characteristics, treatment modalities, outcomes and prognostic factors were analysed.

In total, 314 patients were included. The 5-year overall survival (OS) and progression-free survival (PFS) rates were 49.4% and 24.7%, respectively, in the surgery group; no long-term survivors were observed when surgery was not feasible. Moreover, even after surgery, a high recurrence rate was reported with a median PFS of 22 months. In multivariate analysis, Union for International Cancer Control (UICC) stage and tumour site correlated with PFS and OS. Postoperative radiotherapy (PORT) improved the PFS but not OS in patients with small (T3) SNMM and OCMM tumours. Nodal involvement was more frequent in patients with OCMM (p

Moya-Plana, A., Aup’erin, A., Obongo, R., Baglin, A., Ferrand, F.R., Baujat, B., Saroul, N., Casiraghi, O., Vergez, S., Herman, P., Janot, F., Thariat, J., V’erillaud, B., de Gabory, L., and members, REFCOR. Oncologic outcomes, prognostic factor analysis and therapeutic algorithm evaluation of head and neck mucosal melanomas in France. 24990. 2019 Eur J Cancer (123):

Concepts Keywords
Algorithm Progression-free survival
France Melanoma
French Medical physics
Melanomas Radiation therapy
Metastasis RTT
Metastatic Cancer
Multivariate Analysis Medicine
Nodal Health
Oral Cavity Neoplasms
Prognosis Radiotherapy
Radiotherapy Surgery
TNM Stage Surgery
Tumour Mucosal melanoma

Semantics

Type Source Name
disease MESH Cancer
disease MESH recurrence
disease MESH Head and Neck Cancer
disease MESH metastasis
disease MESH melanomas
pathway KEGG Melanoma

Original Article

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