Study highlights ‘worrying’ increase in misuse of non-opioid medications

Study highlights ‘worrying’ increase in misuse of non-opioid medications

Publication date: Dec 02, 2019

Intentional suspected suicide attempts increased by 80. 3% for isolated gabapentin exposures over a five-year-period and 43% for baclofen over a four-year-period A major new analysis of the non-opioid medications, gabapentin and baclofen, shows “worrying” increases in related suicide attempts and hospital admissions in US adults since 2013 – coinciding with a decrease in opioid prescriptions.

In this latest study, published in Clinical Toxicology, researchers from the University of Pittsburgh looked at over 90,000 cases of exposure to the medications and saw large increases in misuse and toxicity – with isolated abuse instances of using gabapentin (from 2013 to 2017) rising by 119. 9%, and baclofen (2014-2017) 31. 7%.

Intentional suspected suicide attempts increased by 80. 3% for isolated gabapentin exposures over a five-year-period and 43% for baclofen over a four-year-period.

Lead author Kimberly Reynolds, of the University of Pittsburgh, said: “We are seeing a worrying increase in harmful exposures to gabapentin and baclofen in US adults over recent years, which may be an unintended consequence of the move away from opioid prescriptions for pain management.

Concepts Keywords
Baclofen Opioid
Chronic Pain Pain management
Controlled Substance Prescription drug
Gabapentin Anxiolytics
Healthcare Gabapentin
Hospital Baclofen
Mood Disorders Anticonvulsants
Opioid Analgesics
Opioids Calcium channel blockers
Pain Management Health
Pittsburgh RTT
Poison Pain management
Prescribed Medications Chronic pain
Suicidal Ideation Admissions healthcare facility
Suicide Pain
Toxicity
Unintended Consequence

Semantics

Type Source Name
disease MESH chronic pain
drug DRUGBANK Baclofen
drug DRUGBANK Gabapentin
disease MESH suicide
drug DRUGBANK Tropicamide
disease MESH substance use disorders
disease MESH mood disorders
disease MESH suicidal ideation

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