Publication date: Dec 03, 2019
The approach involves a microRNA in the microbiome that increases when MS peaks in mouse models of the disease.
The researchers studied the microbiome of the mouse models of MS and made a surprising discovery: When they took fecal matter from animals experiencing peak symptoms and transferred it to other mice, the animals receiving the material were protected from MS. A closer examination of the microbiome showed that it was not the bacteria itself providing the protection, but rather a microRNA called miR-30d.
The Brigham and Women’s researchers recognize that treating MS with a microRNA from the gut that peaks along with symptoms may be counter-intuitive, but they believe further research into miR-30d could point to new ways for modulating the microbiome.
-Our findings, which show that a microRNA can be used to target and influence the microbiome with precision, may have applicability for MS and many other diseases, including diabetes, ALS, obesity and cancer,” he said in a statement.
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