Treating multiple sclerosis with the help of the gut microbiome

Treating multiple sclerosis with the help of the gut microbiome

Publication date: Dec 03, 2019

The approach involves a microRNA in the microbiome that increases when MS peaks in mouse models of the disease.

The researchers studied the microbiome of the mouse models of MS and made a surprising discovery: When they took fecal matter from animals experiencing peak symptoms and transferred it to other mice, the animals receiving the material were protected from MS. A closer examination of the microbiome showed that it was not the bacteria itself providing the protection, but rather a microRNA called miR-30d.

The Brigham and Women’s researchers recognize that treating MS with a microRNA from the gut that peaks along with symptoms may be counter-intuitive, but they believe further research into miR-30d could point to new ways for modulating the microbiome.

-Our findings, which show that a microRNA can be used to target and influence the microbiome with precision, may have applicability for MS and many other diseases, including diabetes, ALS, obesity and cancer,” he said in a statement.

Concepts Keywords
ALS
Ann Romney
Antibodies
Bacteria
Brain
Brain Diseases
California
Cancer
Central Nervous System
Diabetes
Fecal Matter
Inflammation
Mice
Microbes
Microbiome
MicroRNA
Multiple Sclerosis
Neurological Disorder
Obesity
Peak
Plasma Cells
San Francisco
Toronto
Tregs

Semantics

Type Source Name
disease MESH multiple sclerosis
disease MESH neurological disorder
disease MESH brain diseases
disease MESH inflammation
disease MESH obesity
disease MESH cancer

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