Human p21-activated kinase 5 (PAK5) expression and potential mechanisms in relevant cancers: Basic and clinical perspectives for molecular cancer therapeutics.

Human p21-activated kinase 5 (PAK5) expression and potential mechanisms in relevant cancers: Basic and clinical perspectives for molecular cancer therapeutics.

Publication date: Dec 02, 2019

An oncogenic role, p21-activated kinase 5 (PAK5), has proven as a significant mediator for many cellular progression, which is expressed highly in human organs such as lung, liver, kidney, blood vessels endothelial cells and inflammatory cells. PAK5 was primitively detected in the cerebrum and accelerated the filopodia formation in neurocytes. It can reverse the effect of Rho and adjust its activity to mediate maintenance and development of nerve axon by binding with Cdc42-GTP. Moreover, PAK5 has been suggested to mediate protean, multitudinous and inscrutable functions in cancer. Currently, many researches indicated that PAK5 was dysregulated in ovarian cancer, cervical cancer, melanoma, osteosarcoma, renal carcinoma, breast cancer, gastric cancer and so on, which was involved in cell proliferation, apoptosis, migration and invasion. This review focuses the latest knowledge on the structure, expression, signalling pathway of PAK5, emphasizing its function in cancer.

Li, Y.K., Zou, J., Ye, D.M., Zeng, Y., Chen, C.Y., Luo, G.F., and Zeng, X. Human p21-activated kinase 5 (PAK5) expression and potential mechanisms in relevant cancers: Basic and clinical perspectives for molecular cancer therapeutics. 25039. 2019 Life Sci.

Concepts Keywords
Apoptosis Molecular therapeutics
Axon PAK5
Blood P21-activated kinases
Breast Cancer CDC42
Cancer Apoptosis
Cdc42
Cerebrum
Cervical Cancer
Endothelial
Filopodia
GTP
Kidney
Liver
Lung
Melanoma
Molecular Therapeutics
Nerve
Oncogenic
Osteosarcoma
Ovarian Cancer
Renal Carcinoma
Rho
Sci
Signalling Pathway

Semantics

Type Source Name
disease MESH cancers
disease MESH development
disease MESH ovarian cancer
disease MESH cervical cancer
disease MESH melanoma
pathway KEGG Melanoma
disease MESH osteosarcoma
disease MESH renal
pathway KEGG Apoptosis

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *