Publication date: Dec 10, 2019
Research shows modulation of the Hedgehog and androgen signaling pathways to discontinue the vicious circle leading to inflammation in the central nervous system and chronic demyelination Treatment leads to functional recovery of axons associated with regeneration of myelin sheaths and reversal of pathological microglia activation in the chronic mouse model of experimental autoimmune encephalomyelitis New therapeutic strategy for demyelinating and neuroinflammatory diseases such as multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS) MetP pursues additional patent applications in all major markets worldwide (PCT) EMMETTEN, Switzerland, December 09, 2019 / B3C newswire / — MetP(R) Pharma AG today announced that it has received a Notice of Allowance from the United States Patent and Trademark Office (USPTO) for its patent entitled -Treatment of Demyelinating Diseases” (U. S. Appl.
Valid until 2039, the patent addresses a method to treat demyelinating diseases such as multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) as well as other diseases in which neuroinflammation is a central pathological process.
The patent broadly covers demyelinating and inflammatory diseases of the central nervous system (CNS) such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Devic’s disease and Alzheimer’s disease; and demyelinating diseases of the peripheral nervous system such as Guillain-BarrcE9 syndrome, chronic inflammatory demyelinating polyneuropathy and Anti-MAG peripheral neuropathy.
Contact MetP Pharma AG Dr. Claudia Mattern CSO +41-41-618 30 30 Myelin Sheath; Amyotrophic Lateral Sclerosis 2, Juvenile; Amyotrophic Lateral Sclerosis; Encephalomyelitis, Autoimmune, Experimental; Multiple Sclerosis; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Testosterone; Regenerative Medicine; Administration, Intranasal; Remyelination; Microglia; Signal Transduction; Axons; Central Nervous System; Inflammation Published by B3C newswire and shared through Newronic(R)
|pathway||KEGG||Hedgehog signaling pathway|
|disease||MESH||amyotrophic lateral sclerosis|
|disease||MESH||Polyradiculoneuropathy Chronic Inflammatory Demyelinating|
|disease||MESH||Encephalomyelitis Autoimmune Experimental|
|disease||MESH||Amyotrophic Lateral Sclerosis 2 Juvenile|
|disease||MESH||attention deficit hyperactivity disorder|