Opioid Therapy vs Multimodal Analgesia in Head and Neck Cancer

Publication date: Jan 08, 2020

The purpose of this study is to compare the daily pain level scores for patients taking opioids alone for pain relief, compared with those treated by multimodal analgesia with three medications: pregabalin, naproxen, and acetaminophen, with the ability to switch over to opioid medications if needed. In addition to pain level scores, this study will compare opioid use (length of time and doses taken), quality of life, admissions to hospital, feeding tube requirements, weight loss, and treatment interruptions between these two analgesic regimens.

Concepts Keywords
Acetaminophen Neck pain management
Analgesia Pain
Analgesic Neck pain
Anticonvulsant Tumour
Antidepressant True allergy
Bilirubin Radiation treatment
Bleeding Disorder Chemotherapy
Candidiasis Radiotherapy
Chemotherapy Neck pain management
Creatinine Clearance Drugs
Difficulty Swallowing Psychoactive drugs
Equivalent Dose RTT
Feeding Tube Euphoriants
Gastrostomy Pain
Gy Morphinans
Histologically Opioids
Hospital Analgesic
Ibuprofen Pain management
Infection Radiation therapy
Lactating Heroin
Malignancies Pregabalin
Malignancy Radiation
Malnourishment Chemotherapy
Mol
Morphine
Mucosa
Mucositis
Multimodal
Naproxen
Neck Pain
Neoplasms
NSAIDs
Opioid
Opioids
Pain
Pain Management
Pharmacologic
Pregabalin
Radiation
Radiation Dose
Radiation Treatment
Radiotherapy
Salivary Gland
Steroid
True Allergy
Tumour
Upper Gastrointestinal Bleed
Weight Loss

Semantics

Type Source Name
disease MESH Head and Neck Cancer
drug DRUGBANK Pregabalin
drug DRUGBANK Naproxen
drug DRUGBANK Acetaminophen
disease MESH weight loss
disease MESH malignancy
disease MESH oral candidiasis
disease MESH infection
drug DRUGBANK Morphine
disease MESH Renal
drug DRUGBANK Creatinine
disease MESH Liver Dysfunction
disease MESH allergy
disease MESH bleeding
disease MESH substance use disorder

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