Publication date: Jan 09, 2020
Vitamin D has antineoplastic effects, but the synthesis of vitamin D requires ultraviolet radiation, a known risk factor for melanoma.
To investigate the correlations between serum vitamin D levels and risk and prognosis of melanoma.
A systematic review and meta-analysis was conducted. Online databases were searched on Oct 31, 2018.
Twenty-five studies with a total of 11166 patients with melanoma were included. There was no significant difference in serum vitamin D levels between patients with melanoma and controls (standardized mean difference [SMD], -0.185; 95% confidence interval [CI], -0.533-0.162). However, the prevalence of vitamin D deficiency was significantly higher in patients with melanoma than that in controls (odds ratio, 2.115; 95% CI, 1.151-3.885). In terms of prognosis, serum vitamin D levels were significantly higher in melanoma patients with lower Breslow thickness (? 1 mm vs > 1 mm: SMD, 0.243; 95% CI, 0.160-0.327). Moreover, melanoma patients with lower vitamin D levels had a significantly higher mortality rate (hazard ratio, 1.558; 95% CI, 1.258-1.931).
Vitamin D deficiency is associated with higher Breslow thickness and mortality in melanoma patients.
Tsai, T.Y., Kuo, C.Y., and Huang, Y.C. The association between serum vitamin D level and risk and prognosis of melanoma: A systematic review and meta-analysis. 25430. 2020 J Eur Acad Dermatol Venereol.
|disease||MESH||vitamin D deficiency|