The association between serum vitamin D level and risk and prognosis of melanoma: A systematic review and meta-analysis.

Publication date: Jan 09, 2020

Vitamin D has antineoplastic effects, but the synthesis of vitamin D requires ultraviolet radiation, a known risk factor for melanoma.

To investigate the correlations between serum vitamin D levels and risk and prognosis of melanoma.

A systematic review and meta-analysis was conducted. Online databases were searched on Oct 31, 2018.

Twenty-five studies with a total of 11166 patients with melanoma were included. There was no significant difference in serum vitamin D levels between patients with melanoma and controls (standardized mean difference [SMD], -0.185; 95% confidence interval [CI], -0.533-0.162). However, the prevalence of vitamin D deficiency was significantly higher in patients with melanoma than that in controls (odds ratio, 2.115; 95% CI, 1.151-3.885). In terms of prognosis, serum vitamin D levels were significantly higher in melanoma patients with lower Breslow thickness (? 1 mm vs > 1 mm: SMD, 0.243; 95% CI, 0.160-0.327). Moreover, melanoma patients with lower vitamin D levels had a significantly higher mortality rate (hazard ratio, 1.558; 95% CI, 1.258-1.931).

Vitamin D deficiency is associated with higher Breslow thickness and mortality in melanoma patients.

Tsai, T.Y., Kuo, C.Y., and Huang, Y.C. The association between serum vitamin D level and risk and prognosis of melanoma: A systematic review and meta-analysis. 25430. 2020 J Eur Acad Dermatol Venereol.

Concepts Keywords
Antineoplastic Prevalence vitamin deficiency
Confidence Interval Significantly higher melanoma
Melanoma Radiation
Meta Analysis Health
Mortality RTT
Mortality Rate Branches of biology
Odds Ratio Nutrients
Prognosis Sun tanning
Risk Factor Biomolecules
Serum Nutrition
SMD Vitamin D
Ultraviolet Radiation Melanoma
Vitamin Breslow’s depth
Vitamin Deficiency Folate
Radiation

Semantics

Type Source Name
drug DRUGBANK Vitamin D
disease MESH melanoma
pathway KEGG Melanoma
disease MESH risk factor
disease MESH vitamin D deficiency

Original Article

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