Verbascoside, synthetic derivatives and other glycosides from Argentinian native plant species as potential antitumoral agents.

Publication date: Jan 10, 2020

A phytochemical study was performed on three native plant species from the central-western zone of Argentina: Buddleja cordobensis Grisebach, Baccharis salicina Torr. & A. Gray and Nepeta cataria L. We could obtain verbascoside (1) from B. cordobensis. From N. cataria, we could obtain 1, 5, 9-epi-deoxyloganic acid (2) L. Finally, we could isolate 2-?-(L-rhamnopyranosyl)-3-angeloyloxy-15-acetyloxy-7,13(14)-E-dien-ent-labdane (3) and 2-?-(L-rhamnopyranosyl)-3-?-angeloyloxy-15-hydroxy-7,13(14)-E-dien-ent-labdane (4) from B. salicina. Moreover, three derivatives from 1, and one semi-synthetic derivative from 2, were prepared. PCR reaction was used to analyse the activity against DNA polymerase and cell culture to determine cytotoxicity and antitumoral activity. Verbascoside (1) was strongly active in the nanomolar scale (IC = 356?nM) against DNA polymerization. Moreover, verbascoside was also strongly active in the nanomolar scale against human melanoma cell line (IC = 256?nM) and human colorectal cell line (IC = 320?nM). Furthermore, derivatives 6 and 7 were cytotoxic against both cancer cell lines.

Garro, H.A., Bruna-Haupt, E., , Cianchino, Malizia, F., Favier, S., Menacho-M’arquez, M., Cifuente, D., Fern’andez, C.O., and Pungitore, C.R. Verbascoside, synthetic derivatives and other glycosides from Argentinian native plant species as potential antitumoral agents. 25429. 2020 Nat Prod Res.

Concepts Keywords
Acetyloxy Plants
Acid Organisms
Argentina Perennial plants
Argentinian Carbohydrates
Cytotoxic Phenylethanoids
Cytotoxicity Verbascoside
Derivative Glycoside
Glycosides Catnip
Melanoma Buddleja cordobensis
Nanomolar Nepeta
Native Plant Rhamnose
Nepeta Cataria Labdane
PCR Polymerization
Phytochemical
Polymerase
Polymerization

Semantics

Type Source Name
disease MESH melanoma
pathway KEGG Melanoma
disease MESH cancer

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