Impact of Prenatal Exposure to Opioids, Cocaine, and Cannabis on Eye Disorders in Children.

Publication date: Jan 07, 2020

Prenatal substance exposure is associated with abnormal visual evoked potentials in offspring, but whether ocular abnormalities are present past infancy is unclear. We determined the association between prenatal substance exposure and hospitalizations for eye disorders in childhood.

We conducted a longitudinal cohort study of 794,099 infants born between 2006 and 2016 in all hospital centers in Quebec, Canada. We identified infants prenatally exposed to opioids, cocaine, cannabis, and other illicit substances and followed them over time to assess eye disorders that required in-hospital treatment, including retinal detachment and breaks, strabismus, and other ocular pathologies. We calculated incidence rates and hazard ratios (HR) with 95% confidence intervals (CI) for the association of prenatal substance exposure with risk of eye disorders, adjusted for patient characteristics.

Infants exposed to substances prenatally had a higher incidence of hospitalizations for eye disorders compared with unexposed infants (47.0 vs 32.0 per 10,000 person-years). Prenatal substance exposure was associated with 1.23 times the risk of hospital admission for any eye disorder during childhood compared with no exposure (95% CI 1.04-1.45). Risks were greatest for strabismus (HR 1.55, 95% CI 1.16-2.07) and binocular movement disorders (HR 1.96, 95% CI 1.00-3.83). Opioid use was strongly associated with the risk of ocular muscle disorders (HR 3.15, 95% CI 1.98-5.01).

Prenatal substance exposure is significantly associated with future hospitalizations for eye disorders in childhood. Efforts to minimize substance use in women of reproductive age are needed in light of the current opioid epidemic.

Auger, N., Rh’eaume, M.A., Low, N., Lee, G.E., Ayoub, A., and Luu, T.M. Impact of Prenatal Exposure to Opioids, Cocaine, and Cannabis on Eye Disorders in Children. 04496. 2020 J Addict Med.

Concepts Keywords
Canada Eye disorders
Cannabis Detachment breaks strabismus
Cocaine RTT
Cohort Abnormal psychology
Confidence Intervals Embryology
Evoked Potentials Fertility
Eye Disorders Midwifery
Hospital Prenatal development
Incidence Strabismus
Movement Disorders Opioid
Muscle Addiction
Opioid Anatomy
Opioid Epidemic Human reproduction
Opioids Organ systems
Retinal Detachment


Type Source Name
drug DRUGBANK Cocaine
drug DRUGBANK Medical Cannabis
disease MESH visual
disease MESH abnormalities
disease MESH retinal detachment
disease MESH strabismus
disease MESH movement disorders
disease MESH muscle disorders


Original Article

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