CHIEF PD (CHolinesterase Inhibitor to prEvent Falls in Parkinson’s Disease)

CHIEF PD (CHolinesterase Inhibitor to prEvent Falls in Parkinson’s Disease)

Publication date: Jan 13, 2020

Parkinson’s disease is a common condition particularly affecting older people. Falls are a very frequent complication of the disease affecting 60% of people with Parkinson’s every year. As the population ages, the number of people living with Parkinson’s disease and the occurrence of complications will increase. The loss of the chemical dopamine in the brain causes walking in Parkinson’s to become slower, unsteady and irregular. People with the condition are therefore at a very high risk of falling. To some extent, people can compensate for these changes by paying more attention to their walking. However, Parkinson’s also diminishes memory and thinking ability. This decreases people’s ability to pay attention to their walking, especially when doing something at the same time. Cholinesterase inhibitor (ChEis) are drugs that are currently used to treat people with memory problems in Parkinson’s. The effect of these drugs on falls in Parkinson’s has been tested to show that treatment has the potential to almost halve the number of falls. This trial aims to definitively determine whether cholinesterase inhibitors (ChEi), can prevent falls in Parkinson’s and whether this treatment is cost effective. 600 participants with Parkinson’s disease will be enrolled from hospitals throughout the UK. Participants will be randomly assigned to either receive the drug (ChEi) via a patch or receive a placebo (dummy) treatment via a patch. Neither the researchers nor the participants will know which group they are in. Participants will take the medication for 12 months and record any falls that they experience in diaries. If successful, this treatment in Parkinson’s disease, would tackle one of the most disabling complications of the disease and positive findings will provide robust evidence to change clinical practice.

Concepts Keywords
Brain Hypersensitivity rivastigmine Dementia
Breastfeeding Disease
Bristol Contraception
Cholinesterase Inhibitor Branches of biology
Cholinesterase Inhibitors RTT
Contraception Neuroscience
Dementia Neuropharmacology
Dopamine Aging-associated diseases
Hypersensitivity Psychiatric diagnosis
Idiopathic Cognitive disorders
Memory Parkinson
Parkinson Cholinesterase
Placebo Rivastigmine
Scheduling Dementia


Type Source Name
disease MESH complications
drug DRUGBANK Dopamine
disease MESH Diagnosis
disease MESH aids
disease MESH Hypersensitivity
drug DRUGBANK Rivastigmine
disease MESH Dementia
disease MESH Parkinson Disease
pathway KEGG Parkinson disease


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