Publication date: Jan 11, 2020
The purpose of this study was to identify differences between genetically undefined (GU) early-onset Parkinson’s disease (EOPD) patients and carriers of Parkin mutations on non-motor symptoms (NMSs). EOPD patients (N?=?261) underwent targeted sequencing of Parkinson’s disease (PD) related genes. Among them, 53 cases carried homozygous or compound heterozygous Parkin mutations (Parkin group) while 208 did not carry known causative PD mutations or risk factors of GBA or Parkin heterozygous mutations (GU group). NMSs were evaluated by face-to-face interviews, self-completed questionnaires and results on a neuropsychological battery. Linear regression and logistic regression models were applied to assess the predictors of NMSs. Parkin patients had younger ages of onset (AOO) (p?
Song, J., Shen, B., Yang, Y.J., Liu, F.T., Zhao, J., Tang, Y.L., Chen, C., Ding, Z.T., An, Y., Wu, J.J., Sun, Y.M., and Wang, J. Non-motor Symptoms in Parkinson’s Disease Patients with Parkin Mutations: More Depression and Less Executive Dysfunction. 23619. 2020 J Mol Neurosci.
|Battery||Branches of biology|
|Logistic Regression||Compound heterozygosity|