Non-motor Symptoms in Parkinson’s Disease Patients with Parkin Mutations: More Depression and Less Executive Dysfunction.

Publication date: Jan 11, 2020

The purpose of this study was to identify differences between genetically undefined (GU) early-onset Parkinson’s disease (EOPD) patients and carriers of Parkin mutations on non-motor symptoms (NMSs). EOPD patients (N?=?261) underwent targeted sequencing of Parkinson’s disease (PD) related genes. Among them, 53 cases carried homozygous or compound heterozygous Parkin mutations (Parkin group) while 208 did not carry known causative PD mutations or risk factors of GBA or Parkin heterozygous mutations (GU group). NMSs were evaluated by face-to-face interviews, self-completed questionnaires and results on a neuropsychological battery. Linear regression and logistic regression models were applied to assess the predictors of NMSs. Parkin patients had younger ages of onset (AOO) (p?

Song, J., Shen, B., Yang, Y.J., Liu, F.T., Zhao, J., Tang, Y.L., Chen, C., Ding, Z.T., An, Y., Wu, J.J., Sun, Y.M., and Wang, J. Non-motor Symptoms in Parkinson’s Disease Patients with Parkin Mutations: More Depression and Less Executive Dysfunction. 23619. 2020 J Mol Neurosci.

Concepts Keywords
Battery Branches of biology
Causative RTT
Heterozygous Psychiatric diagnosis
Homozygous Genetics
Linear Regression Parkin
Logistic Regression Compound heterozygosity
Neuropsychological Mutation
Parkinson
Sequencing

Semantics

Type Source Name
drug DRUGBANK Trihexyphenidyl
drug DRUGBANK Profenamine
disease MESH Depression
disease MESH risk factors

Original Article

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