The effect of sex on multiple sclerosis risk and disease progression.

Publication date: Jan 22, 2020

Sex differences in the incidence or severity of disease characterize many autoimmune and neurodegenerative diseases. Multiple sclerosis is a complex disease with both autoimmune and neurodegenerative aspects and is characterized by sex differences in susceptibility and progression. Research in the study sex differences is a way to capitalize on a known clinical observation, mechanistically disentangle it at the laboratory bench, then translate basic research findings back to the clinic as a novel treatment trial tailored to optimally benefit each sex. This “Bedside to Bench to Bedside” approach based on sex differences in MS will be reviewed here, first for disease susceptibility then for disability progression.

Voskuhl, R.R. The effect of sex on multiple sclerosis risk and disease progression. 20044. 2020 Mult Scler.

Concepts Keywords
Autoimmune Neuroimmunology
Disability Experimental autoimmune encephalomyelitis
Incidence Autoimmune diseases
Multiple Sclerosis Neuroscience
Neurodegenerative Mind–body interventions
Neurodegenerative Diseases Neurology
Organ systems
Medical specialties
Multiple sclerosis
Multiple sclerosis


Type Source Name
disease MESH multiple sclerosis
disease MESH disease progression
disease MESH neurodegenerative diseases
pathway REACTOME Neurodegenerative Diseases
disease MESH experimental autoimmune encephalomyelitis

Original Article

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