Hypertension, Antihypertensive Use and the Delayed-Onset of Huntington’s Disease.

Publication date: Feb 04, 2020

Hypertension is a modifiable cardiovascular risk factor implicated in neurodegeneration and dementia risk. In Huntington’s disease, a monogenic neurodegenerative disease, autonomic and vascular abnormalities have been reported. This study’s objective was to examine the relationship between hypertension and disease severity and progression in Huntington’s disease.

Using longitudinal data from the largest worldwide observational study of Huntington’s disease (n = 14,534), we assessed the relationship between hypertension, disease severity, and rate of clinical progression in Huntington’s disease mutation carriers. Propensity score matching was used to statistically match normotensive and hypertensive participants for age, sex, body mass index, ethnicity, and CAG length.

Huntington’s disease patients had a lower prevalence of hypertension compared with age-matched gene-negative controls. Huntington’s disease patients with hypertension had worse cognitive function, a higher depression score, and more marked motor progression over time compared with Huntington’s disease patients without hypertension. However, hypertensive patients taking antihypertensive medication had less motor, cognitive, and functional impairment than Huntington’s disease patients with untreated hypertension and a later age of clinical onset compared with untreated hypertensive patients and normotensive individuals with Huntington’s disease.

We report the novel finding that hypertension and antihypertensive medication use are associated with altered disease severity, progression, and clinical onset in patients with Huntington’s disease. These findings have implications for the management of hypertension in Huntington’s disease and suggest that prospective studies of the symptomatic or disease-modifying potential of antihypertensives in neurodegenerative diseases are warranted. (c) 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Open Access PDF

Steventon, J.J., Rosser, A.E., Hart, E., and Murphy, K. Hypertension, Antihypertensive Use and the Delayed-Onset of Huntington’s Disease. 06912. 2020 Mov Disord.

Concepts Keywords
Antihypertensive Medication Antihypertensive drug
Antihypertensives Hypertension
Autonomic Circulatory system
Body Mass Cardiovascular system
Cardiovascular Medicine
Cognitive Lower prevalence hypertension
Cognitive Function Authors Movement Disorders
Dementia Prospective symptomatic disease
Depression Disease Hypertension
Gene Monogenic neurodegenerative disease
Huntington Relationship hypertension
Hypertension Neurodegeneration dementia
Monogenic Cardiovascular disease
Movement Disorders White coat hypertension
Mutation Orthostatic hypertension
Neurodegeneration Blood pressure
Neurodegenerative Disease
Neurodegenerative Diseases
Parkinson
Risk Factor
Wiley Periodicals Inc

Semantics

Type Source Name
disease MESH Hypertension
disease MESH risk factor
disease MESH dementia
disease MESH neurodegenerative disease
disease MESH abnormalities
disease MESH depression
pathway REACTOME Neurodegenerative Diseases
disease MESH Movement Disorders

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