Psychiatric Disorders Share Common Neural Circuit, Emotion Processing Dysfunction

Psychiatric Disorders Share Common Neural Circuit, Emotion Processing Dysfunction

Publication date: Feb 06, 2020

A common pattern of aberrant brain activation during emotional processing may contribute to the pathophysiology of psychiatric disorders, according to a meta-analysis published in the American Journal of Psychiatry.

The results of the study point to the validity of the Research Domain Criteria initiative and suggest that neuroimaging findings may not be specific to certain psychiatric disorders.

Lisa M. McTeague, PhD, of the department of psychiatry and behavioral sciences at the Medical University of South Carolina, Charleston, and colleagues searched PubMed for whole-brain functional neuroimaging studies comparing activation during emotional processing tasks in patients with psychiatric disorders and healthy controls.

Nonetheless, the findings of the study point to coordinated network disruptions that affect adaptive emotional expression and regulation and these networks may prove to be effective targets for therapeutic interventions.

Identification of common neural circuit disruptions in emotional processing across psychiatric disorders.

Concepts Keywords
Amygdala Magnetic resonance imaging
Anterior Insula ALE
Anxiety Hippocampus
Brain Ventromedial prefrontal cortex
Charleston Amygdala
Cingulate Neuroscience
Common Orbitofrontal cortex
Comorbidities Frontal lobe
Convergence Limbic system
Emotion Neuropsychology
FMRI Cerebral cortex
Functional Neuroimaging Brain
Hippocampal Dysfunction
McTeague However limited disorders
Meta Analysis Agreement principal disorder
Mood Disorders Pathophysiology psychiatric disorders
Neural Circuit Chronic disorders
Neuroimaging Imaging
Occipital Cortex
Parahippocampal Gyri
Psychiatric Disorders
Psychiatric Illness
South Carolina
Ventrolateral Prefrontal Cortex
Ventromedial Prefrontal Cortex


Type Source Name
disease MESH Psychiatric Disorders
disease MESH schizophrenia
disease MESH disorders anxiety
disease MESH substance use disorders
disease MESH diagnosis
disease MESH abnormalities

Original Article

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