Specific antibodies reacting to JC polyomavirus capsid protein mimotopes in sera from multiple sclerosis and other neurological diseases-affected patients.

Publication date: Feb 03, 2020

Published data support the hypothesis that viruses could be trigger agents of multiple sclerosis onset. This link is based on evidence of early exposure to viral agents in patients affected by this neurologic disease. JC (JC polyomavirus [JCPyV]), BK (BKPyV), and simian virus 40 (SV40) neurotropic polyomavirus footprints have been detected in brain tissue specimens and samples from patients affected by different neurological diseases. In this investigation, serum samples from patients affected by multiple sclerosis and other inflammatory and noninflammatory neurologic diseases, as well as healthy subjects representing the control, were investigated for immunoglobulin G (IgG) antibodies against JCPyV. To this end, an immunologic approach was employed, which consists of employing indirect enzyme-linked immunosorbent assay testing with synthetic peptides mimicking viral capsid protein 1 antigens. A significantly lower prevalence of IgG antibodies against JCPyV VP1 epitopes, with a low titer, was detected in serum samples from patients with multiple sclerosis (MS) and other neurologic diseases than in healthy subjects. Our study indicates that the prevalence of JCPyV antibodies from patients with multiple sclerosis is 50% lower than in healthy subjects, suggesting specific immune impairments. These results indicate that patients affected by neurological diseases, including MS, respond poorly to JCPyV VP1 antigens, suggesting specific immunologic dysfunctions.

Mazzoni, E., , Bononi, Pietrobon, S., Torreggiani, E., Rossini, M., Pugliatti, M., , Casetta, Castellazzi, M., Granieri, E., Guerra, G., Martini, F., and Tognon, M. Specific antibodies reacting to JC polyomavirus capsid protein mimotopes in sera from multiple sclerosis and other neurological diseases-affected patients. 20146. 2020 J Cell Physiol.

Concepts Keywords
Antibodies Agents multiple sclerosis
Antigens Medical specialties
Brain Medicine
Capsid Branches of biology
Epitopes Polyomaviridae
IgG Antibody
Immunoglobulin Human polyomavirus 2
JC Polyomavirus VP1
Multiple Sclerosis STL polyomavirus
Neurologic Disease Antibodies
Neurologic Diseases
Neurological Diseases
Neurotropic
Peptides
Polyomavirus
Serum
Simian
SV40
Titer
Viral
Virus
Viruses

Semantics

Type Source Name
disease MESH multiple sclerosis

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