Thalamostriatal degeneration contributes to dystonia and cholinergic interneuron dysfunction in a mouse model of Huntington’s disease.

Publication date: Feb 07, 2020

Huntington’s disease (HD) is an autosomal dominant trinucleotide repeat disorder characterized by choreiform movements, dystonia and striatal neuronal loss. Amongst multiple cellular processes, abnormal neurotransmitter signalling and decreased trophic support from glutamatergic cortical afferents are major mechanisms underlying striatal degeneration. Recent work suggests that the thalamostriatal (TS) system, another major source of glutamatergic input, is abnormal in HD although its phenotypical significance is unknown. We hypothesized that TS dysfunction plays an important role in generating motor symptoms and contributes to degeneration of striatal neuronal subtypes. Our results using the R6/2 mouse model of HD indicate that neurons of the parafascicular nucleus (PF), the main source of TS afferents, degenerate at an early stage. PF lesions performed prior to motor dysfunction or striatal degeneration result in an accelerated dystonic phenotype and are associated with premature loss of cholinergic interneurons. The progressive loss of striatal medium spiny neurons and parvalbumin-positive interneurons observed in R6/2 mice is unaltered by PF lesions. Early striatal cholinergic ablation using a mitochondrial immunotoxin provides evidence for increased cholinergic vulnerability to cellular energy failure in R6/2 mice, and worsens the dystonic phenotype. The TS system therefore contributes to trophic support of striatal interneuron subtypes in the presence of neurodegenerative stress, and TS deafferentation may be a novel cell non-autonomous mechanism contributing to the pathogenesis of HD. Furthermore, behavioural experiments demonstrate that the TS system and striatal cholinergic interneurons are key motor-network structures involved in the pathogenesis of dystonia. This work suggests that treatments aimed at rescuing the TS system may preserve important elements of striatal structure and function and provide symptomatic relief in HD.

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Crevier-Sorbo, G., Rymar, V.V., Crevier-Sorbo, R., and Sadikot, A.F. Thalamostriatal degeneration contributes to dystonia and cholinergic interneuron dysfunction in a mouse model of Huntington’s disease. 06922. 2020 Acta Neuropathol Commun (8):1.

Concepts Keywords
Ablation Striatum
Afferents Neurons
Autosomal Dominant Cerebrum
Cholinergic Addiction
Cortical Nervous system
Deafferentation Neuroscience
Degenerate Brain
Dystonia Motor dysfunction
Dystonic Pathogenesis dystonia
Energy Dystonia
Glutamatergic Choreiform movements
Huntington Interneuron
Immunotoxin Medium spiny neuron
Interneuron Basal ganglia
Interneurons Cholinergic
Medium Spiny Neurons D. James Surmeier
Mice
Mitochondrial
Neurodegenerative
Neurons
Neurotransmitter
Parvalbumin
Pathogenesis
Phenotype
Phenotypical
Progressive
Stress
Striatal
Trinucleotide Repeat Disorder
Trophic

Semantics

Type Source Name
disease MESH choreiform movements

Original Article

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