The Susceptibility of Human Melanoma Cells to Infection with the Leningrad-16 Vaccine Strain of Measles Virus.

Publication date: Feb 04, 2020

Oncolytic viruses, including live attenuated measles virus (MV) vaccine strains, have recently been shown as promising therapeutic agents against human malignancies. In this study, the oncolytic potential of the attenuated vaccine strain Leningrad-16 (L-16) of MV was evaluated in a panel of human metastatic melanoma cell lines. The L-16 measles virus was shown to replicate within melanoma cells mediating direct cell killing of tumor cells, although all melanoma cell lines varied in regard to their ability to respond to L-16 MV infection, as revealed by the different pattern of the Interferon Stimulated Gene expression, cytokine release and mechanisms of cell death. Furthermore, the statistically significant L-16 measles virus related tumor growth inhibition was demonstrated in a melanoma xenograft model. Therefore, L-16 MV represents an appealing oncolytic platform for target delivery of therapeutic genes along with other attenuated measles virus strains.

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Ammour, Y., Ryabaya, O., Shchetinina, Y., Prokofeva, E., Gavrilova, M., Khochenkov, D., Vorobyev, D., Faizuloev, E., , Shohin, Zverev, V.V., Svitich, O., and Nasedkina, T. The Susceptibility of Human Melanoma Cells to Infection with the Leningrad-16 Vaccine Strain of Measles Virus. 25748. 2020 Viruses (12):2.

Concepts Keywords
Attenuated Vaccine Virotherapy
Cytokine Experimental cancer treatments
Infection Virology
Interferon RTT
Leningrad Vaccination
Malignancies Microbiology
Measles Medical specialties
Measles Virus Medicine
Melanoma Immunotherapy
Oncolytic Panel metastatic melanoma
Oncolytic Viruses Infection
Tumor Oncolytic virus
Vaccine Vaccine
Xenograft Melanoma

Semantics

Type Source Name
disease MESH Melanoma
pathway KEGG Melanoma
disease MESH Infection
disease MESH malignancies
disease MESH growth

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