Clinical Trial for Near Infrared Endoventricular Illumination for Neuroprotection in Very Early Cases of Parkinson’s Disease (Ev-NIRT)

Clinical Trial for Near Infrared Endoventricular Illumination for Neuroprotection in Very Early Cases of Parkinson’s Disease (Ev-NIRT)

Publication date: Feb 10, 2020

Parkinson’s disease has only pharmacological (essentially dopaminergic) and surgical treatment (essentially high-frequency deep brain stimulation), that are symptomatically effective. none of them is curative, and has the ability to slow down the disease and to protect dopaminergic neurons from death by neurodegeneration. Experimental results, based on preclinical studies, suggest that brain illumination in the Near-InfraRed (NIR) range is likely to slow down this neurodegenerative process. Thus, a medical device system (called Ev-NIRT) has been developed for 670 nm intracerebral illumination of the substantia nigra pars compacta (SNpc), and is planned to be tested for the treatment of Parkinson’s disease. In this pilot study the investigators will evaluate the feasibility and tolerance of surgery and brain illumination thanks to the Ev-NIRT medical device, in a group of 7 de novo Parkinson’s patients implanted with the innovative medical device. Patients will be monitored for 4 years.

Concepts Keywords
Anesthetic Implantable devices
Beck Depression Inventory Control
Brain Disease
Brain Damage Claustrophobia
Breastfeeding Surgical treatment
Cerebellum Surgery
Claustrophobia Deep brain stimulation
Clinical Trial Medicine
Cluster Headache Health
Cognitive Impairment Basal ganglia
Contraindication Midbrain
Control Group Branches of biology
Deep Brain Stimulation Neurosurgical procedures
Dopamine Agonist Neuroprosthetics
Dopaminergic Neurotechnology
Electrical Energy Deep brain stimulation
Evolution Pars compacta
French Substantia nigra
Frequency Clinical trial
Grenoble Magnetic Resonance Imaging
Herpes Tomography
Hypothalamus MRI
Idiopathic
Implantation
Infection
Magnetic Resonance Imaging
Major Depressive Episode
Minimally Invasive
MRI
Neurodegeneration
Neurodegenerative
Neurologist
Neurology
Neurons
Neuroprotection
Neuroprotective
NIR
Parkinson
Parkinsonian
Parturient
Pathology
PET
PET Scan
Pharmacological
Positron Emission Tomography
Prosthesis
Psychiatric Disorder
Psychosis
Psychotropic
Social Security
Striatum
Syndrome
Tracer
Treatment Modality
Tremor
Ventricular
Virus
White Matter

Semantics

Type Source Name
disease MESH death
disease MESH Diagnosis
disease MESH tremor
disease MESH Depression
disease MESH psychiatric disorder
disease MESH complications
disease MESH syndrome
disease MESH vascular malformation
disease MESH contraindication
disease MESH infection
disease MESH claustrophobia
disease MESH cognitive impairment
drug DRUGBANK Levodopa
disease MESH pathology
disease MESH psychosis
disease MESH Parkinson Disease
pathway KEGG Parkinson disease

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