Neural Cell Adhesion Molecule (NCAM) a Serum Biomarker Indicative for the Severity of Cervical Spondylotic Myelopathy.

Publication date: Feb 07, 2020

Peripheral blood samples were obtained from 25 patients with cervical spondylotic myelopathy (CSM) and 13 healthy volunteers.

Our aim was to investigate the significance of neurodegenerative biomarkers in patients with CSM and correlate their expression with CSM severity.

CSM is a common disorder involving chronic progressive compression of the cervical spinal resulting in progressive neurological impairment that ranges from mild tingling in the upper limbs to complete quadriplegia. However, the immunological background related to the neurodegenerative damage and its significance in CSM is still unclear.

Protein expression profiles of 14 neurodegenerative biomarkers were measured by multiplex Luminex bead assay and further analyzed by group comparison statistics, correlation studies, and receiver-operating characteristic analysis.

Eleven of 14 biomarkers were significantly elevated in CSM patients as compared with healthy subjects (P

Akshota, N., Friedlander, A., Hershkovich, O., Gurevich, M., Givon, U., Sakhini, M., and Achiron, A. Neural Cell Adhesion Molecule (NCAM) a Serum Biomarker Indicative for the Severity of Cervical Spondylotic Myelopathy. 20181. 2020 Clin Spine Surg.

Concepts Keywords
Assay Chronic progressive compression
Bead CSM common disorder
Biomarker Medicine
Biomarkers Clinical medicine
Blood Branches of biology
Cervical Biomarkers
Correlation Myelopathy
Multiplex
Myelopathy
NCAM
Neurodegenerative
Neurological
Progressive
Quadriplegia
Receiver Operating Characteristic
Spondylotic Myelopathy

Semantics

Type Source Name
disease MESH Myelopathy
disease MESH quadriplegia

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