Nanocatalytic activity of clean-surfaced, faceted nanocrystalline gold enhances remyelination in animal models of multiple sclerosis.

Nanocatalytic activity of clean-surfaced, faceted nanocrystalline gold enhances remyelination in animal models of multiple sclerosis.

Publication date: Feb 11, 2020

Development of pharmacotherapies that promote remyelination is a high priority for multiple sclerosis (MS), due to their potential for neuroprotection and restoration of function through repair of demyelinated lesions. A novel preparation of clean-surfaced, faceted gold nanocrystals demonstrated robust remyelinating activity in response to demyelinating agents in both chronic cuprizone and acute lysolecithin rodent animal models. Furthermore, oral delivery of gold nanocrystals improved motor functions of cuprizone-treated mice in both open field and kinematic gait studies. Gold nanocrystal treatment of oligodendrocyte precursor cells in culture resulted in oligodendrocyte maturation and expression of myelin differentiation markers. Additional in vitro data demonstrated that these gold nanocrystals act via a novel energy metabolism pathway involving the enhancement of key indicators of aerobic glycolysis. In response to gold nanocrystals, co-cultured central nervous system cells exhibited elevated levels of the redox coenzyme nicotine adenine dinucleotide (NAD+), elevated total intracellular ATP levels, and elevated extracellular lactate levels, along with upregulation of myelin-synthesis related genes, collectively resulting in functional myelin generation. Based on these preclinical studies, clean-surfaced, faceted gold nanocrystals represent a novel remyelinating therapeutic for multiple sclerosis.

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Robinson, A.P., Zhang, J.Z., Titus, H.E., Karl, M., Merzliakov, M., Dorfman, A.R., Karlik, S., Stewart, M.G., Watt, R.K., Facer, B.D., Facer, J.D., Christian, N.D., Ho, K.S., Hotchkin, M.T., Mortenson, M.G., Miller, R.H., and Miller, S.D. Nanocatalytic activity of clean-surfaced, faceted nanocrystalline gold enhances remyelination in animal models of multiple sclerosis. 20190. 2020 Sci Rep (10):1.

Concepts Keywords
Adenine
Aerobic
ATP
Central Nervous System
Coenzyme
Extracellular
Gait
Glycolysis
Gold
Intracellular
Kinematic
Lactate
Metabolism
Multiple Sclerosis
Myelin
NAD+
Nanocrystal
Neuroprotection
Nicotine
Oligodendrocyte
Redox
Rodent
Sci

Semantics

Type Source Name
drug DRUGBANK Gold
disease MESH multiple sclerosis
disease MESH Development
disease MESH gait
drug DRUGBANK Nicotine
drug DRUGBANK Adenine
drug DRUGBANK ATP
drug DRUGBANK Coenzyme M
drug DRUGBANK Montelukast
disease MESH metabolic stress
drug DRUGBANK Dextrose unspecified form
drug DRUGBANK Nadide
drug DRUGBANK NADH
pathway KEGG Oxidative phosphorylation
drug DRUGBANK Water
drug DRUGBANK Sodium bicarbonate
pathway KEGG Metabolic pathways
drug DRUGBANK Tretamine
drug DRUGBANK Trestolone
disease MESH demyelination
drug DRUGBANK Copper
pathway KEGG Apoptosis
drug DRUGBANK Chlorpromazine
drug DRUGBANK Pyridoxal Phosphate
disease MESH **p
drug DRUGBANK Proline
disease MESH tic
disease MESH posture
drug DRUGBANK L-Lysine
drug DRUGBANK Liothyronine
disease MESH separated
disease MESH fructose
drug DRUGBANK Fructose
disease MESH repression
disease MESH shock
pathway KEGG Fatty acid metabolism
drug DRUGBANK Oxygen
disease MESH neurodegenerative diseases
drug DRUGBANK Methionine
disease MESH amyotrophic lateral sclerosis
disease MESH Optic Neuropathy
disease MESH visual
drug DRUGBANK Rotenone
disease MESH immuno
drug DRUGBANK Pentaerythritol tetranitrate
drug DRUGBANK Silver
drug DRUGBANK Platinum
drug DRUGBANK Isoxaflutole
pathway KEGG Pentose phosphate pathway
drug DRUGBANK Hydrogen peroxide
disease MESH death
drug DRUGBANK Diethylstilbestrol
disease MESH aging
disease MESH Optic neuritis
drug DRUGBANK PYM50028
drug DRUGBANK Etoperidone

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