A Physician-Completed Digital Tool for Evaluating Disease Progression (Multiple Sclerosis Progression Discussion Tool): Validation Study.

Publication date: Feb 12, 2020

Defining the transition from relapsing-remitting multiple sclerosis (RRMS) to secondary progressive multiple sclerosis (SPMS) can be challenging and delayed. A digital tool (MSProDiscuss) was developed to facilitate physician-patient discussion in evaluating early, subtle signs of multiple sclerosis (MS) disease progression representing this transition.

This study aimed to determine cut-off values and corresponding sensitivity and specificity for predefined scoring algorithms, with or without including Expanded Disability Status Scale (EDSS) scores, to differentiate between RRMS and SPMS patients and to evaluate psychometric properties.

Experienced neurologists completed the tool for patients with confirmed RRMS or SPMS and those suspected to be transitioning to SPMS. In addition to age and EDSS score, each patient’s current disease status (disease activity, symptoms, and its impacts on daily life) was collected while completing the draft tool. Receiver operating characteristic (ROC) curves determined optimal cut-off values (sensitivity and specificity) for the classification of RRMS and SPMS.

Twenty neurologists completed the draft tool for 198 patients. Mean scores for patients with RRMS (n=89), transitioning to SPMS (n=47), and SPMS (n=62) were 38.1 (SD 12.5), 55.2 (SD 11.1), and 69.6 (SD 12.0), respectively (P

Open Access PDF

Ziemssen, T., Piani-Meier, D., Bennett, B., Johnson, C., Tinsley, K., Trigg, A., Hach, T., Dahlke, F., Tomic, D., Tolley, C., and Freedman. A Physician-Completed Digital Tool for Evaluating Disease Progression (Multiple Sclerosis Progression Discussion Tool): Validation Study. 20192. 2020 J Med Internet Res (22):2.

Concepts Keywords
Digital Health
Multiple Sclerosis Relapsing–remitting
Physician Spms
Progressive Clinical medicine
Psychometric Multiple sclerosis
Receiver Operating Characteristic MS
ROC Multiple sclerosis
Tool Status disease
EDSS
Neurology
Multiple sclerosis research

Semantics

Type Source Name
disease MESH Disease Progression
disease MESH Multiple Sclerosis
disease MESH relapsing-remitting multiple sclerosis
disease MESH secondary progressive multiple sclerosis
drug DRUGBANK Saquinavir

Original Article

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