DNA damage and repair in Parkinson’s disease: Recent advances and new opportunities.

Publication date: Feb 12, 2020

Parkinson’s disease (PD) is the most common movement neurodegenerative disorder. Although our understanding of the underlying mechanisms of pathogenesis in PD has greatly expanded, this knowledge thus far has failed to translate into disease-modifying therapies. Therefore, it is of the utmost urgency to interrogate further the multifactorial etiology of PD. DNA repair defects cause many neurodegenerative diseases. An exciting new PD research avenue is the role that DNA damage and repair may play in neuronal death. The goal of this mini-review was to discuss the evidence for the types of DNA damage that accumulates in PD, which has provided clues for which DNA repair pathways, such as DNA double-strand break repair, are dysfunctional. We further highlight compelling data for activation of the DNA damage response in familial and idiopathic PD. The significance of DNA damage and repair is emerging in the PD field and linking these insights to PD pathogenesis may provide new insights into PD pathophysiology and consequently lead to new therapies.

Gonzalez-Hunt, C.P. and Sanders, L.H. DNA damage and repair in Parkinson’s disease: Recent advances and new opportunities. 23970. 2020 J Neurosci Res.

Concepts Keywords
Etiology Neurodegenerative diseases
Idiopathic Branches of biology
Neurodegenerative Diseases Organ systems
Neurodegenerative Disorder Neurological disorders
Parkinson Nervous system
Pathogenesis Neurodegeneration
Pathophysiology Neuroscience
Senescence
Pathophysiology
Neurodegenerative disorders

Semantics

Type Source Name
disease MESH DNA damage
disease MESH neurodegenerative disorder
pathway REACTOME DNA Repair
disease MESH defects
disease MESH death

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