Effectiveness of interventions aimed at improving the sexuality of women with multiple sclerosis: a systematic review.

Publication date: Feb 12, 2020

To evaluate the effectiveness of interventions aimed at improving the sexuality of women with multiple sclerosis.

MEDLINE, CINAHL, PsycINFO, Web of Science, Scopus, Embase and the Cochrane Library, as well as doctoral thesis databases Teseo and ProQuest Dissertations & Theses Global and the grey literature database Opengrey were searched, last on 15 October 2019. Journals related to the topic were also consulted. The bibliographic references of the articles included were reviewed.

Studies were selected if they included women with multiple sclerosis in whom interventions aimed at reducing sexual dysfunction were applied. Data extraction was carried out by two independent reviewers. The Jadad scale was used to evaluate the methodological quality of the studies included.

In total, 12 clinical trials were selected, and 611 patients were examined. Studies were classified into six interventions: sexual therapy (4), pharmaceutical drugs (3), pelvic floor exercises (2), yoga (1), mindfulness (1) and vaginal devices (1). Most of them improved some primary outcomes of sexual dysfunction such as lubrication, arousal, desire or orgasm. Pain was the most common secondary outcome evaluated and it became better in two studies including sexual therapy and in one intervention with pelvic floor exercises. Tertiary outcomes such as anxiety or depression were rarely examined, and they improved with sexual therapy and with OnabotulinumtoxinA.

Sexual therapy, administration of OnabotulinumtoxinA, pelvic floor muscles exercises alone or combined with electrostimulation and the use of clitoral devices could be the most recommended interventions to improve the sexuality in women with multiple sclerosis.

Esteve-R’ios, A., Garcia-Sanjuan, S., Oliver-Roig, A., and Caba~nero-Mart’inez, M.J. Effectiveness of interventions aimed at improving the sexuality of women with multiple sclerosis: a systematic review. 20194. 2020 Clin Rehabil.

Concepts Keywords
Anxiety Vaginal devices
Arousal Electrostimulation clitoral devices
CINAHL Pharmaceutical drugs
Clinical Trials Pain
Clitoral Sexual reproduction
Cochrane Library Behavior
Depression Human reproduction
Electrostimulation Sexology
Embase Sexual health
Lubrication Women’s health
MEDLINE Physical exercise
Mindfulness Sex therapy
Multiple Sclerosis Kegel exercise
OnabotulinumtoxinA Sexual dysfunction
Orgasm Multiple sclerosis
Pelvic Floor Sexual intercourse
Pharmaceutical
ProQuest
PsycINFO
Scopus
Sexual Dysfunction
Sexual Therapy
Systematic Review
Tertiary
Yoga

Semantics

Type Source Name
disease MESH multiple sclerosis
drug DRUGBANK Tropicamide
disease MESH anxiety
disease MESH depression
drug DRUGBANK Botulinum Toxin Type A

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