Publication date: Feb 08, 2020
Our recent genetic-neuroimaging study observed that the rs1799724 polymorphism within the TNFA gene encoding TNF-? selectively affects the anatomy of visual cortex in patients with MDD. In this study, we hypothesized that TNFA is risk factor to MDD, and TNFA rs1799724 polymorphism may be a susceptibility locus for this disorder and its clinical features.
We enrolled 807 MDD samples and 822 healthy volunteers in Eastern China. There were 104 drug-na”ive first episode MDD patients recruited. The Hamilton Rating Scale for Depression -17 (HRSD-17) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were performed to evaluate the severity of depressive symptoms and cognitive function, respectively.
Patients with MDD have higher levels of TNFA than healthy controls (F = 20.78, P
Zhao, J., Hua, S., Wang, W., Fan, W., Tang, W., Zhang, Y., and Zhang, C. Identification of TNFA influencing MDD risk and clinical features in Han Chinese. 21006. 2020 Cytokine (129):
|disease||MESH||Major depressive disorder|