Innate Immunity: A Common Denominator between Neurodegenerative and Neuropsychiatric Diseases.

Innate Immunity: A Common Denominator between Neurodegenerative and Neuropsychiatric Diseases.

Publication date: Feb 07, 2020

The intricate relationships between innate immunity and brain diseases raise increased interest across the wide spectrum of neurodegenerative and neuropsychiatric disorders. Barriers, such as the blood-brain barrier, and innate immunity cells such as microglia, astrocytes, macrophages, and mast cells are involved in triggering disease events in these groups, through the action of many different cytokines. Chronic inflammation can lead to dysfunctions in large-scale brain networks. Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal dementia, are associated with a substrate of dysregulated immune responses that impair the central nervous system balance. Recent evidence suggests that similar phenomena are involved in psychiatric diseases, such as depression, schizophrenia, autism spectrum disorders, and post-traumatic stress disorder. The present review summarizes and discusses the main evidence linking the innate immunological response in neurodegenerative and psychiatric diseases, thus providing insights into how the responses of innate immunity represent a common denominator between diseases belonging to the neurological and psychiatric sphere. Improved knowledge of such immunological aspects could provide the framework for the future development of new diagnostic and therapeutic approaches.

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Novellino, F., , Sacc`a, Donato, A., Zaffino, P., Spadea, M.F., Vismara, M., Arcidiacono, B., Malara, N., , Presta, and Donato, G. Innate Immunity: A Common Denominator between Neurodegenerative and Neuropsychiatric Diseases. 06928. 2020 Int J Mol Sci (21):3.

Concepts Keywords
Alzheimer Neuroscience
Amyotrophic Lateral Sclerosis Psychiatric diagnosis
Astrocytes Cognitive disorders
Autism Spectrum Disorders Organ systems
Blood Brain Barrier Senescence
Brain Diseases Nervous system
Central Nervous System Branches of biology
Common Common denominator diseases
Cytokines Traumatic stress disorder
Depression Degenerative disease
Frontotemporal Dementia Neurodegeneration
Huntington Frontotemporal dementia
Innate Immunity
Neurodegenerative Diseases


Type Source Name
disease MESH brain diseases
disease MESH inflammation
disease MESH Neurodegenerative diseases
pathway REACTOME Neurodegenerative Diseases
disease MESH amyotrophic lateral sclerosis
disease MESH frontotemporal dementia
drug DRUGBANK Isoxaflutole
disease MESH psychiatric diseases
disease MESH depression
disease MESH schizophrenia
disease MESH autism spectrum disorders
disease MESH post-traumatic stress disorder
disease MESH development
disease MESH depressive disorders

Original Article

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