Juntendo University Research: Light-activated Protein Treats Parkinson’s Disease in a Fly Model

Juntendo University Research: Light-activated Protein Treats Parkinson’s Disease in a Fly Model

Publication date: Feb 13, 2020

TOKYO, Feb. 13, 2020 /PRNewswire/ — A light-sensitive protein can restore mitochondria function in fruit flies bearing a gene mutation associated with Parkinson’s disease and relieve its symptoms, report researchers at Juntendo University in the journal Communications Biology.

Yuzuru Imai and Nobutaka Hattori at Juntendo University and colleagues at the University of Shizuoka and Waseda University in Japan have now developed a light-activated protein, named mito-Delta-rhodopsin (mito-dR), that restores mitochondrion function in a fruit fly model of the disease.

Previous research has pointed towards mutations in the protein coding gene CHCHD2 as the cause of the disease, as well as identifying a number of cellular processes that the disease affects.

In terms of energy generating processes, production of ATP – the energy currency in cells – is diminished and the generation of reactive oxygen species increases.

Mitochondrial functions involve the interplay of complex reaction cycles, redox processes and electrochemical forces.

Electrons that prematurely reduce oxygen in this process can lead to reactive oxygen species and cause oxidative stress to the mitochondria, which is related to age-related mitochondrial decline.

The mission of Juntendo University is to strive for advances in society through education, research, and healthcare, guided by the motto “Jin – I exist as you exist” and the principle of “Fudan Zenshin – Continuously Moving Forward”.

With the creation of Juntendo, the founders hoped to create a place where people could come together with the shared goal of helping society through the powers of medical education and practices.

Through the years the institution’s experience and perspective as an institution of higher education and a place of clinical practice has enabled Juntendo University to play an integral role in the shaping of Japanese medical education and practices.

Today, Juntendo University continues to pursue innovative approaches to international level education and research with the goal of applying the results to society.

Concepts Keywords
Actively Transported Citric acid cycle
Amino Acids Redox
ATP Adenosine triphosphate
Bacteria Parkin
Ca2+ Mitochondrial matrix
Calcium Electron transport chain
Chemical Energy Electrochemical gradient
Citric Mitochondrion
Citric Acid Cycle Chemiosmosis
Cofactors Branches of biology
Cognitive Physical sciences
Currency Students healthcare professionals
Dementia Energy currency
Depression Transfer chemicals
Dizziness Amounts energy
Dopamine Lead disease
Dopaminergic CHCHD2 disease
Drosophila
Dutch
Electrochemical
Electrochemical Gradient
Electron Transport
Electron Transport Chain
Endocrine
Energy
Fruit Flies
Fruit Fly
Fukushima
Genetic Modification
Glucose
H+
Healthcare
Higher Education
Hormones
Hospital
Hydrogen
Integral
Intermembrane Space
International Education
Interplay
Ion
Ion Transport
Isomerization
Japan
Japanese
Jin
Journal Communications
Juntendo University
Locomotor Activity
Medicine
Membrane
Membrane Potential
Mito
Mitochondria
Mitochondrial
Mitochondrial Matrix
Mitochondrial Membrane
Mitochondrion
Molecule
Mutation
NADH
Nerve
Nerve Pain
Nervous System
Neuron
Neurons
Neurotransmitters
Nursing
Oxidative Stress
Oxygen
Parkinson
Protein
Proton
Proton Motive Force
Protonmotive Force
Pump Protons
Pyruvate
Reactive Oxygen Species
Redox
Retinal
Rhodopsin
Salt
Shizuoka
Signal Transduction
Society
Stiffness
Transmembrane
Vitamin

Semantics

Type Source Name
drug DRUGBANK Oxygen
drug DRUGBANK Dopamine
drug DRUGBANK ATP
disease MESH nerve pain
disease MESH dementia
disease MESH depression
drug DRUGBANK NADH
drug DRUGBANK Dextrose unspecified form
drug DRUGBANK Nonoxynol-9
drug DRUGBANK Amino acids
drug DRUGBANK Vitamin A
disease MESH oxidative stress
drug DRUGBANK Flunarizine

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