Myelin Measurement Using Quantitative Magnetic Resonance Imaging: A Correlation Study Comparing Various Imaging Techniques in Patients with Multiple Sclerosis.

Publication date: Feb 08, 2020

Evaluation of myelin by magnetic resonance imaging (MRI) is a difficult challenge, but holds promise in demyelinating diseases, such as multiple sclerosis (MS). Although multiple techniques have been developed, no gold standard has been established. This study aims to evaluate the correlation between synthetic MRI myelin volume fraction (SyMRI) and myelin fraction estimated by other techniques, i.e., magnetization transfer saturation (MTsat), T1-weighted images divided by T2-weighted images (T1w/T2w), and radial diffusivity (RD) in patients with MS. We also compared the sensitivities of these techniques for detecting MS-related myelin damage. SyMRI, MTsat, T1w/T2w, and RD were averaged on plaque, periplaque white matter, and normal-appearing white matter (NAWM). Pairwise correlation was calculated using Spearman’s correlation analysis. For all segmented regions, strong correlations were found between SyMRI and T1w/T2w (Rho = 0.89), MTsat (Rho = 0.82), or RD (Rho = -0.75). For each technique, the average estimated myelin differed significantly among regions, but the percentage change of NAWM from both periplaque white matter and plaque were highest in SyMRI. SyMRI might be suitable for myelin evaluation in MS patients, with relevant results as compared to other well-studied techniques. Moreover, it presented better sensitivity for the detection of the difference between plaque or periplaque white matter and NAWM.

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Saccenti, L., Hagiwara, A., Andica, C., Yokoyama, K., Fujita, S., Kato, S., Maekawa, T., Kamagata, K., Le Berre, A., Hori, M., Wada, A., Tateishi, U., Hattori, N., and Aoki, S. Myelin Measurement Using Quantitative Magnetic Resonance Imaging: A Correlation Study Comparing Various Imaging Techniques in Patients with Multiple Sclerosis. 20198. 2020 Cells (9):2.

Concepts Keywords
Correlation Magnetic resonance imaging
Demyelinating Diseases Multiple sclerosis
Gold Standard White matter
Magnetic Resonance Imaging Demyelinating disease
Magnetization Neurological disorders
MRI Branches of biology
Multiple Sclerosis Nervous system
Myelin Organ systems
Rho MS
T2 Weighted Demyelinating diseases
Volume Fraction Multiple Sclerosis
White Matter MRI
Magnetic Resonance Imaging

Semantics

Type Source Name
disease MESH Multiple Sclerosis
disease MESH demyelinating diseases
drug DRUGBANK Gold
drug DRUGBANK Tropicamide

Original Article

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