New study provides clear picture of brain abnormalities associated with schizophrenia

New study provides clear picture of brain abnormalities associated with schizophrenia

Publication date: Feb 13, 2020

Now, thanks to the pooled data and insights from researchers around the world, USC researchers have the clearest picture yet of brain abnormalities associated with the serious mental illness that impacts 20 million people worldwide.

About a quarter of people with 22q develop schizophrenia or experience psychotic symptoms, so studying the syndrome provides a unique window into how such psychiatric problems develop over time.

To get a clear picture of the brain abnormalities associated with schizophrenia in individuals with 22q, the study’s authors examined magnetic resonance imaging (MRI) scans from 533 people with the disorder and 330 healthy control subjects.

Notably, the brain changes seen in people with 22q and psychosis significantly overlapped with the brain changes observed in previous neuroimaging studies of schizophrenia and other serious mental illnesses including bipolar disorder, major depression and obsessive-compulsive disorder.

Concepts Keywords
22q MRI
Amygdala Magnetic resonance imaging
Analytic Mechanisms of schizophrenia
Australia Childhood schizophrenia
Bipolar Disorder Paul Thompson
Brain Psychosis
Canada Schizophrenia
Chromosome DiGeorge syndrome
Control Group Branches of biology
Depression Abnormal psychology
DiGeorge Syndrome Psychopathology
Europe RTT
Genetic Psychiatry
Genetic Disorder Magnetic resonance imaging
Hippocampus Deletion syndrome
INI
Magnetic Resonance Imaging
Magnitude
Mental Illness
MRI
Neuroimaging
Obsessive Compulsive Disorder
Paul Thompson
Psychosis
Psychotic
Risk Factor
Schizophrenia
South America
Syndrome
Thalamus
USC

Semantics

Type Source Name
disease MESH psychiatric illnesses
disease MESH obsessive-compulsive disorder
disease MESH depression
disease MESH bipolar disorder
disease MESH rare diseases
disease MESH syndrome
disease MESH risk factor
disease MESH genetic disorder
disease MESH 22q11.2 deletion syndrome
drug DRUGBANK Tropicamide
disease MESH schizophrenia
disease MESH abnormalities
disease MESH psychosis

Original Article

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