Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.

Publication date: Feb 12, 2020

The structural integrity and functional stability of organelles are prerequisites for the viability and responsiveness of cells. Dysfunction of multiple organelles is critically involved in the pathogenesis and progression of various diseases, such as chronic obstructive pulmonary disease, cardiovascular diseases, infection, and neurodegenerative diseases. In fact, those organelles synchronously present with evident structural derangement and aberrant function under exposure to different stimuli, which might accelerate the corruption of cells. Therefore, the quality control of multiple organelles is of great importance in maintaining the survival and function of cells and could be a potential therapeutic target for human diseases. Organelle-specific autophagy is one of the major subtypes of autophagy, selectively targeting different organelles for quality control. This type of autophagy includes mitophagy, pexophagy, reticulophagy (endoplasmic reticulum), ribophagy, lysophagy, and nucleophagy. These kinds of organelle-specific autophagy are reported to be beneficial for inflammatory disorders by eliminating damaged organelles and maintaining homeostasis. In this review, we summarized the recent findings and mechanisms covering different kinds of organelle-specific autophagy, as well as their involvement in various diseases, aiming to arouse concern about the significance of the quality control of multiple organelles in the treatment of inflammatory diseases.Abbreviations: ABCD3: ATP binding cassette subfamily D member 3; AD: Alzheimer disease; ALS: amyotrophic lateral sclerosis; AMBRA1: autophagy and beclin 1 regulator 1; AMPK: AMP-activated protein kinase; ARIH1: ariadne RBR E3 ubiquitin protein ligase 1; ATF: activating transcription factor; ATG: autophagy related; ATM: ATM serine/threonine kinase; BCL2: BCL2 apoptosis regulator; BCL2L11/BIM: BCL2 like 11; BCL2L13: BCL2 like 13; BECN1: beclin 1; BNIP3: BCL2 interacting protein 3; BNIP3L/NIX: BCL2 interacting protein 3 like; CALCOCO2/NDP52: calcium binding and coiled-coil domain 2; CANX: calnexin; CAT: catalase; CCPG1: cell cycle progression 1; CHDH: choline dehydrogenase; COPD: chronic obstructive pulmonary disease; CSE: cigarette smoke exposure; CTSD: cathepsin D; DDIT3/CHOP: DNA-damage inducible transcript 3; DISC1: DISC1 scaffold protein; DNM1L/DRP1: dynamin 1 like; EIF2AK3/PERK: eukaryotic translation initiation factor 2 alpha kinase 3; EIF2S1/eIF2?: eukaryotic translation initiation factor 2 alpha kinase 3; EMD: emerin; EPAS1/HIF-2?: endothelial PAS domain protein 1; ER: endoplasmic reticulum; ERAD: ER-associated degradation; ERN1/IRE1?: endoplasmic reticulum to nucleus signaling 1; FBXO27: F-box protein 27; FKBP8: FKBP prolyl isomerase 8; FTD: frontotemporal dementia; FUNDC1: FUN14 domain containing 1; G3BP1: G3BP stress granule assembly factor 1; GBA: glucocerebrosidase beta; HIF1A/HIF1: hypoxia inducible factor 1 subunit alpha; IMM: inner mitochondrial membrane; LCLAT1/ALCAT1: lysocardiolipin acyltransferase 1; LGALS3/Gal3: galectin 3; LIR: LC3-interacting region; LMNA: lamin A/C; LMNB1: lamin B1; LPS: lipopolysaccharide; MAPK8/JNK: mitogen-activated protein kinase 8; MAMs: mitochondria-associated membranes; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MFN1: mitofusin 1; MOD: multiple organelles dysfunction; MTPAP: mitochondrial poly(A) polymerase; MUL1: mitochondrial E3 ubiquitin protein ligase 1; NBR1: NBR1 autophagy cargo receptor; NLRP3: NLR family pyrin domain containing 3; NUFIP1: nuclear FMR1 interacting protein 1; OMM: outer mitochondrial membrane; OPTN: optineurin; PD: Parkinson disease; PARL: presenilin associated rhomboid like; PEX3: peroxisomal biogenesis factor 3; PGAM5: PGAM family member 5; PHB2: prohibitin 2; PINK1: PTEN induced putative kinase 1; PRKN: parkin RBR E3 ubiquitin protein ligase; RB1CC1/FIP200: RB1 inducible coiled-coil 1; RETREG1/FAM134B: reticulophagy regulator 1; RHOT1/MIRO1: ras homolog family member T1; RIPK3/RIP3: receptor interacting serine/threonine kinase 3; ROS: reactive oxygen species; RTN3: reticulon 3; SEC62: SEC62 homolog, preprotein translocation factor; SESN2: sestrin2; SIAH1: siah E3 ubiquitin protein ligase 1; SNCA: synuclein alpha; SNCAIP: synuclein alpha interacting protein; SQSTM1/p62: sequestosome 1; STING1: stimulator of interferon response cGAMP interactor 1; TAX1BP1: Tax1 binding protein 1; TBK1: TANK binding kinase 1; TFEB: transcription factor EB; TICAM1/TRIF: toll-like receptor adaptor molecule 1; TIMM23: translocase of inner mitochondrial membrane 23; TNKS: tankyrase; TOMM: translocase of the outer mitochondrial membrane; TRIM: tripartite motif containing; UCP2: uncoupling protein 2; ULK1: unc-51 like autophagy activating kinase; UPR: unfolded protein response; USP10: ubiquitin specific peptidase 10; VCP/p97: valosin containing protein; VDAC: voltage dependent anion channels; XIAP: X-linked inhibitor of apoptosis; ZNHIT3: zinc finger HIT-type containing 3.

Open Access PDF

Yao, R.Q., Ren, C., Xia, Z.F., and Yao, Y.M. Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles. 23968. 2020 Autophagy.

Concepts Keywords
Acyltransferase Alpha
ALS ULK1
Alzheimer Ubiquitin
AMP BNIP3
AMPK Stress granule
Amyotrophic Lateral Sclerosis Mitophagy
Apoptosis Autophagy
Ariadne Posttranslational modification
Assembly Membrane proteins
ATF Mitochondria
ATM Cell biology
ATP Binding Cassette Branches of biology
Autophagy CAT
BCL2 Apoptosis
BIM ATG
Biogenesis ATM
Calcium
Cardiovascular Diseases
Catalase
Cathepsin
CHOP
Cigarette Smoke
Coiled Coil
COPD
DNA Damage
Dynamin
EIF2
EMD
Endoplasmic Reticulum
Endothelial
ER
FMR1
Frontotemporal Dementia
Galectin
HIF1A
Homeostasis
Homolog
Hypoxia
Infection
Inflammatory Diseases
Inflammatory Disorders
Interferon
JNK
Kinase
Lamin
Lamin A
Lipopolysaccharide
LIR
LMNA
LPS
Microtubule
Mitochondria
Mitochondrial
Mitochondrial Membrane
Mitogen
Neurodegenerative Diseases
NLRP3
Nucleus
OMM
Organelle
Organelles
Outer Mitochondrial Membrane
Parkin
Parkinson Disease
Pathogenesis
Peroxisomal
PINK1
PolyA
Polymerase
Preprotein
Presenilin
PRKN
Prolyl Isomerase
Protein
PTEN
Pyrin Domain
RB1
Reactive Oxygen Species
Receptor
Rhomboid
ROS
Serine
SNCA
Subfamily
Threonine
Transcription Factor
Translocation
Ubiquitin Ligase

Semantics

Type Source Name
pathway KEGG Autophagy
disease MESH chronic obstructive pulmonary disease
disease MESH cardiovascular diseases
disease MESH infection
disease MESH neurodegenerative diseases
pathway KEGG Mitophagy
disease MESH Alzheimer disease
pathway KEGG Alzheimer disease
disease MESH amyotrophic lateral sclerosis
drug DRUGBANK Serine
drug DRUGBANK L-Threonine
pathway KEGG Apoptosis
drug DRUGBANK Calcium
pathway KEGG Cell cycle
drug DRUGBANK Choline
drug DRUGBANK Aminosalicylic Acid
disease MESH frontotemporal dementia
disease MESH hypoxia
disease MESH Parkinson disease
pathway KEGG Parkinson disease
drug DRUGBANK Trihexyphenidyl
drug DRUGBANK Profenamine
drug DRUGBANK Rasagiline
drug DRUGBANK Trimebutine
drug DRUGBANK Zinc

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *