Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth.

Publication date: Feb 11, 2020

Growing evidence supports the importance of gut microbiota in the control of tumor growth and response to therapy. Here, we select prebiotics that can enrich bacterial taxa that promote anti-tumor immunity. Addition of the prebiotics inulin or mucin to the diet of C57BL/6 mice induces anti-tumor immune responses and inhibition of BRAF mutant melanoma growth in a subcutaneously implanted syngeneic mouse model. Mucin fails to inhibit tumor growth in germ-free mice, indicating that the gut microbiota is required for the activation of the anti-tumor immune response. Inulin and mucin drive distinct changes in the microbiota, as inulin, but not mucin, limits tumor growth in syngeneic mouse models of colon cancer and NRAS mutant melanoma and enhances the efficacy of a MEK inhibitor against melanoma while delaying the emergence of drug resistance. We highlight the importance of gut microbiota in anti-tumor immunity and the potential therapeutic role for prebiotics in this process.

Open Access PDF

Li, Y., Elm’en, L., , Segota, Xian, Y., Tinoco, R., Feng, Y., Fujita, Y., Segura Mu~noz, R.R., Schmaltz, R., Bradley, L.M., Ramer-Tait, A., Zarecki, R., Long, T., Peterson, S.N., and Ronai, Z.A. Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth. 25779. 2020 Cell Rep (30):6.

Concepts Keywords
BRAF Medical specialties
Colon Digestive system
Drug Resistance Bacteriology
Gut Microbiota Medicine
Immune Response Branches of biology
Inulin Prebiotic
Melanoma Melanoma
Mice Inulin
Microbiota Human gastrointestinal microbiota
Mucin
Mutant
Prebiotics
Subcutaneously
Taxa
Tumor

Semantics

Type Source Name
disease MESH tumor
disease MESH Growth
drug DRUGBANK Inulin
disease MESH melanoma
pathway KEGG Melanoma
disease MESH colon cancer

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *