Precision Medicine in Non-Communicable Diseases.

Publication date: Feb 07, 2020

The increase in life expectancy during the 20th century ranks as one of society’s greatest achievements, with massive growth in the numbers and proportion of the elderly, virtually occurring in every country of the world. The burden of chronic diseases is one of the main consequences of this phenomenon, severely hampering the quality of life of elderly people and challenging the efficiency and sustainability of healthcare systems. Non-communicable diseases (NCDs) are considered a global emergency responsible for over 70% of deaths worldwide. NCDs are also the basis for complex and multifactorial diseases such as hypertension, diabetes, and obesity. The epidemics of NCDs are a consequence of a complex interaction between health, economic growth, and development. This interaction includes the individual genome, the microbiome, the metabolome, the immune status, and environmental factors such as nutritional and chemical exposure. To counteract NCDs, it is therefore essential to develop an innovative, personalized, preventative, early care model through the integration of different molecular profiles of individuals to identify both the critical biomarkers of NCD susceptibility and to discover novel therapeutic targets.

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Novelli, G., Biancolella, M., Latini, A., Spallone, A., Borgiani, P., and Papaluca, M. Precision Medicine in Non-Communicable Diseases. 06321. 2020 High Throughput (9):1.

Concepts Keywords
Biomarkers Pharmacogenetics
Chronic Diseases Biomarker
Communicable Diseases Pharmacogenomics
Diabetes Systems biology
Economic Growth Metabolome
Genome Metabolism
Healthcare Bioinformatics
Hypertension Clinical medicine
Metabolome Medicine
Microbiome Branches of biology
Obesity
Society
Sustainability
Throughput

Semantics

Type Source Name
disease MESH Non-Communicable Diseases
disease MESH growth
disease MESH chronic diseases
disease MESH emergency
disease MESH hypertension
disease MESH obesity
drug DRUGBANK Coenzyme M
disease MESH diagnosis
disease MESH genetic diseases
disease MESH cancer
disease MESH neurodegenerative disorders
disease MESH lifestyle
disease MESH aging
drug DRUGBANK Pentaerythritol tetranitrate
disease MESH community
drug DRUGBANK Nonoxynol-9
disease MESH cystic fibrosis
disease MESH epilepsy
drug DRUGBANK Carbamazepine
disease MESH syndrome
drug DRUGBANK Mercaptopurine
disease MESH acute lymphoblastic leukemia
drug DRUGBANK Cefadroxil
drug DRUGBANK Methionine
drug DRUGBANK Adalimumab
drug DRUGBANK Ustekinumab
disease MESH age related macular degeneration
disease MESH inflammatory bowel diseases
disease MESH autism
disease MESH schizophrenia
disease MESH rare diseases
disease MESH neuromuscular diseases
drug DRUGBANK Zalcitabine
drug DRUGBANK Entacapone
drug DRUGBANK Pramipexole
drug DRUGBANK Abacavir
disease MESH Suicide
drug DRUGBANK Bismuth subgallate
disease MESH lung adenocarcinomas
disease MESH adenocarcinoma
disease MESH psoriatic arthritis
disease MESH psoriasis
disease MESH Allergy
disease MESH Cardiovascular Diseases
disease MESH Stroke
disease MESH autism spectrum disorder
pathway KEGG Insulin secretion

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