Quantitative MRI markers in Parkinson’s disease and parkinsonian syndromes.

Publication date: Feb 11, 2020

In Parkinson’s disease and parkinsonian disorders, the differential diagnosis is still challenging. We aim to review current developments in MRI quantitative markers and their potential in a clinical and neuroscientific setting.

There have been efforts to improve MRI acquisition methods and to explore new promising biomarkers. In parallel, technological advances in data analysis (i.e. deep learning) open new ways to use these biomarkers. The MRI markers may differ according to the brain structure investigated. Even if the newly adopted acquisition protocols served mainly the development of brainstem-related biomarkers (neuromelanin MRI, nigrosome sensitive MRI), more established markers (e.g. morphometric values) in basal ganglia, cortex and cerebellum demonstrate their relevance especially to differential diagnosis in parkinsonian syndromes.

We provide an overview on recent advances in MRI quantitative markers of Parkinson’s disease that we divide for didactic purposes in three anatomical levels – cortical/cerebellum structures, basal ganglia and brainstem. We show the complementarity of new biomarkers sensitive to brain tissue properties to established morphometrics.

Arribarat, G. and P’eran, P. Quantitative MRI markers in Parkinson’s disease and parkinsonian syndromes. 23964. 2020 Curr Opin Neurol.

Concepts Keywords
Basal Ganglia Parkinsonian disorders
Biomarkers Branches of biology
Brain Clinical medicine
Brainstem Biomarkers
Cerebellum Cell biology
Complementarity Magnetic resonance imaging
Cortex Human brain
Cortical Basal ganglia
Deep Learning Acquisition protocols
Differential Diagnosis
Parkinsonian Disorders


Type Source Name
disease MESH syndromes
disease MESH parkinsonian disorders
disease MESH diagnosis
disease MESH development

Original Article

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